Table 1 List of adult Indian rhesus macaques examined
Route | Animal Number | Age (Years) | Sex a | SIVMAC251 Dosage (TCID50 b) | Mamu-A*01 Allele | Mamu B*17 Allele | Progressor | Major Pathological Findings |
|---|---|---|---|---|---|---|---|---|
Intravaginal (Ivag) | BC35 | 12.0 | F | 300 | - | ND | - | - |
CL86 | 10.4 | F | 500 | - | ND | + | Severe lymphoid hyperplasia and dysplasia in spleen, all lymph nodes, tonsil, and many other organs; Mild intestinal pneumonia | |
CL87 | 10.0 | F | 300 | - | ND | - | - | |
DE50 | 9.4 | F | 500 | - | - | + | Generalized amyloidosis and lymphoid hyperplasia | |
FK88 | 5.9 | F | 500 | - | - | + | Mild to moderate lymphoid hyperplasia and dysplasia in spleen, multiple lymph nodes and organs | |
GN91 | 3.8 | F | 500 | - | - | - | - | |
Intrarectal (IR) | AE14 | 8.0 | M | 500 | - | - | + | Amyloid deposits in the liver; small number of pneumocystis and SIV giant cells in lung; Cryptosporidium infection in small intestine |
AP09 | 7.3 | M | 500 | + | - | - | - | |
AP64 | 7.0 | M | 500 | - | - | - | - | |
BG21 | 6.3 | M | 500 | - | - | - | - | |
N107 | 12.4 | M | 500 | - | - | - | - | |
P205 | 11.4 | F | 500 | - | - | + | Amyloidosis in the small intestine and enterocolitis; lesions in lung are typical of viral pneumonia with presence of SIV giant cells | |
T153 | 9.5 | F | 500 | + | - | - | - |