Fig. 1
a Plasma viral load and absolute CD4+ T-lymphocyte counts over the course of 257 days for intravaginally (Ivag, n = 6, upper rows) and 272 days for intrarectally (IR, n = 7, bottom rows) SIVMAC251 inoculated macaques were shown. One macaques, GN91 was able to maintain plasma viral load to approximately 1 × 103 RNA copies/ml of plasma following the initial peak of infection. The remaining macaques retained a high viral load throughout infection amongst which CL86, DE50, FK88, AE14 and P205 progressed to AIDS rapidly and were euthanized accordingly. Note GN91 was able to preserve peripheral CD4+ T-cell population after SIV infection for upto 150dpi. b Pearson coefficient of determination analysis between plasma viral load and either total immunoglobulins or antigen specific immunoglobulins were shown for all macaques following SIVMAC251 inoculation for all time points. No significant correlation between plasma viral load and total or antigen-specific immunoglobulin responses were detected in two macaques (AP64 and P205) for all time specified above. Additionally, no significant correlations were found for WVL-specific IgA or peptide-specific IgM for Env and Nef. No Tat or Nef-specific IgA responses were detected. R and P denote Pearson R and probability values respectively for each row when correlated with plasma viral load. NS denotes non-significant P-value (p > 0.05). ND denotes a correlation cannot be calculated. Significant correlation values were shown in bold numbers