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Table 1 Tissue Culture Infectious Dose50 (TCID50) of EV-A71 mutants in comparison with the wild type EV-A71 strain 41

From: Identification of molecular determinants of cell culture growth characteristics of Enterovirus 71

EV-A71 Mutants TCID50
A158T 1.00 × 104
C475T 1.00 × 106
A486G 1.00 × 104
G487A 7.50 × 105
A5262G 3.41 × 105
Partial Deletant (PD) 5′-NTR 1.00 × 106
Positive Control (EV-A71 strain 41) 1.00 × 103
  1. RD cells were infected with the EV-A71 wild type and mutant viruses at a MOI of 0.1. The TCID50/ml values are calculated using the Reed and Muench formula determined from two independent experiments [26]
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