HBsAg and HBeAg in the prediction of a clinical response to peginterferon α-2b therapy in Chinese HBeAg-positive patients

Table 2 Prediction of CR by HBV DNA and serological biomarkers

		CR (+)	CR (−)	PPV	NPV
HBsAg	Week 12
	Up to 1500 IU/mL	13	25	34.2	-
	1500 - 20000 IU/mL	17	68	20.0	-
	Over 20000 IU/mL	3	45	-	93.8
	Week 12 Change
	Up to −1.5 log IU/mL	5	6	45.5	-
	− 1.5 ~ −0.5 log IU/mL	14	37	27.5	-
	Over −0.5 log IU/mL	14	95	-	87.2
	Week 24
	Up to 1500 IU/mL	15	42	26.3	-
	1500 - 20000 IU/mL	18	64	22.0	-
	Over 20000 IU/mL	0	32	-	100.0
	Week 24 Change
	Up to −1.5 log IU/mL	10	20	33.3	-
	− 1.5 ~ −0.5 log IU/mL	11	44	20.0	-
	Over −0.5 log IU/mL	12	74	-	86.0
HBeAg	Week 12
	Up to 10 IU/mL	19	37	33.9	-
	10 - 100 IU/mL	5	31	13.9	-
	Over 100 IU/mL	9	70	-	88.6
	Week 12 Change
	Up to −1.5 log IU/mL	15	31	32.6	-
	− 1.5 ~ −0.5 log IU/mL	11	34	24.4	-
	Over −0.5 log IU/mL	7	73	-	91.3
	Week 24
	Up to 10 IU/mL	24	53	31.2	-
	10 - 100 IU/mL	4	24	14.3	-
	Over 100 IU/mL	5	61	-	92.4
	Week 24 Change
	Up to −1.5 log IU/mL	23	46	33.3	-
	− 1.5 ~ −0.5 log IU/mL	8	29	21.6	-
	Over −0.5 log IU/mL	2	63	-	96.9
HBV DNA	Week 12
	Up to 20000 IU/mL	12	16	42.9	-
	Over 20000 IU/mL	21	122	-	85.3
	Week 12 Change
	Up to −2.0 log IU/mL	18	33	35.3	-
	Over −2.0 log IU/mL	15	105	-	87.5
	Week 24
	Up to 20000 IU/mL	19	32	37.3	-
	Over 20000 IU/mL	14	106	-	88.3
	Week 24 Change
	Up to −2.0 log IU/mL	24	53	31.2	-
	Over −2.0 log IU/mL	9	85	-	90.4

ISSN: 1743-422X