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Table 5 Nucleotide sequence mutation at L2 of 24 HPV-58 isolates

From: L1 and L2 gene polymorphisms in HPV-58 and HPV-33: implications for vaccine design and diagnosis

Sequence pattern

HPV58 L2 Nucleotide sequence

n

Sub-lineages

 

4

4

4

4

4

4

4

4

4

4

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

  
 

4

4

5

5

5

6

6

6

9

9

0

0

0

1

1

2

2

3

3

4

4

4

4

5

5

  
 

5

7

4

5

7

0

2

2

3

4

0

0

1

1

4

0

6

2

9

3

6

8

8

4

7

  
 

2

0

9

8

0

9

1

7

5

5

0

0

4

9

3

6

6

6

5

7

7

2

9

0

9

  

D90400

G

G

T

A

G

A

A

T

A

A

G

G

A

A

T

A

G

A

G

A

A

A

G

A

A

  

KU550639

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

33

A1

KU550640

-

-

-

-

-

-

-

C

-

-

-

-

-

-

-

G

-

-

-

-

-

-

-

-

-

4

A1

KU550641

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

-

-

-

-

-

-

-

-

18

A1

KU550642

-

-

-

-

-

-

-

C

-

-

-

-

-

-

-

-

-

-

C

-

-

-

A

-

-

5

A1

KU550643

-

-

-

-

-

-

-

C

-

-

-

-

-

-

-

-

-

T

C

-

-

-

A

-

-

1

A1

KU550644

-

-

-

-

-

-

C

C

-

-

-

-

-

-

-

-

-

T

C

-

-

-

A

-

-

1

A1

KU550645

-

-

-

-

-

-

C

C

-

-

-

-

-

-

-

-

-

-

C

-

-

-

A

-

-

36

A1

KU550646

-

A

-

-

-

-

C

C

-

-

-

-

-

-

-

-

-

-

C

-

-

-

A

-

-

6

A1

KU550647

-

-

-

-

-

-

C

C

-

-

-

C

-

-

-

-

-

-

C

-

-

-

A

-

-

1

A1

KU550648

A

-

-

-

-

-

C

C

-

-

-

-

-

-

-

-

-

-

C

-

-

-

A

-

-

4

A1

KU550649

-

-

-

G

-

-

C

C

-

-

-

-

-

-

-

-

-

-

C

-

-

-

A

-

-

1

A1

KU550650

-

-

G

G

-

-

C

C

-

-

-

-

-

-

-

-

-

-

C

-

-

-

A

-

-

4

A1

KU550651

-

-

-

-

-

-

-

C

-

G

-

-

G

G

G

-

A

-

C

-

C

-

A

-

-

10

A2

KU550652

-

-

-

-

-

-

C

C

-

G

-

-

G

G

G

-

A

-

C

-

C

-

A

-

-

2

A2

KU550653

-

-

-

-

-

-

C

C

-

G

-

-

G

G

G

-

A

-

C

-

-

-

A

C

-

1

A2

KU550654

-

-

-

-

-

G

-

C

-

G

-

-

G

G

G

-

A

-

C

-

-

-

A

C

-

2

A2

KU550655

-

-

-

-

-

-

-

C

-

G

-

-

G

G

G

-

A

C

C

-

-

-

A

C

-

8

A2

KU550656

-

-

-

-

-

-

-

C

-

G

-

-

G

G

G

-

A

-

C

-

-

T

A

C

-

7

A2

KU550657

-

-

-

-

-

-

-

C

-

G

-

-

G

G

G

-

A

-

C

-

-

-

A

C

-

25

A2

KU550658

-

-

-

-

-

-

-

C

-

G

-

-

G

G

G

-

A

-

C

G

-

-

A

C

-

6

A2

KU550659

-

-

-

-

-

-

-

C

-

G

T

-

G

G

G

-

A

-

C

G

-

-

A

C

-

1

A2

KU550660

-

-

-

-

A

G

-

C

-

-

-

-

-

-

-

-

-

-

C

-

-

-

A

-

-

1

A3

KU550661

-

-

-

-

-

-

-

-

C

-

-

-

-

-

-

-

A

-

C

-

-

-

A

-

C

2

A3

KU550662

-

-

-

-

A

G

-

C

C

-

-

-

-

-

-

-

A

-

C

-

-

-

A

-

C

22

A3

         

N

 

D

D

          

A

T

M

  
 

G

S

      

2

 

2

2

          

4

4

4

  

aa mutation

7

7

-

-

-

-

-

-

3

-

5

5

-

-

-

-

-

-

-

-

-

-

1

3

4

201

 
 

0

6

      

1

 

3

3

          

6

3

6

  
 

E

N

      

T

 

Y

H

          

T

P

L

  

second structure

-

-

-

-

-

-

-

-

-

S

S

S

-

S

S

-

-

-

S

-

-

-

S

-

-

  
  1. Note: D90400 was used as reference. The nucleotides conserved with respect to the reference sequence are marked with a dash(-), whereas a variation position was indicated by a letter. Predicted amino acid changes were also shown. The “S” in the last row of the table means Sheet, the “H” means Helix
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Virology Journal

ISSN: 1743-422X