Skip to main content

Table 3 Baseline minority resistance mutations detected by ultra-deep sequencing

From: Pre-treatment minority HIV-1 drug resistance mutations and long term virological outcomes: is prediction possible?

ID

Virological outcome after at least 6 months of HAART

Genotype

Baseline resistance mutations (% prevalence)

Drug activity of initiated regimen (Based on drug resistance mutation surveillance list [31])

Drug activity of initiated regimen (Based on impact of treatment efficacy Stanford HIVdb algorithm)

NRTIs

NNRTIs

TAMS

L001

Suppressed

C

D67E (1.67)

T69N (1.25)

F77L (2.16)

P225H (1.35)

F227L (2.36)

1

TDF and FTC resistance

EFV resistance

TDF susceptible

FTC susceptible

EFV resistance

L009

Detectable viremia (<1000 RNA copies/ml)

C

D67E (1.29)

T69N (1.03)

F77L (1.15)

L100I (1.15)

KI03N (4.17)

F227L (1.49)

1

TDF and FTC resistance

EFV resistance

TDF susceptible

FTC susceptible

EFV high level resistance

L013

Virological failure

C

D67E (1.73)

T69N (1.21)

F77L (1.13)

P225H (1.16)

F227L (1.98)

1

TDF and FTC resistance

EFV resistance

TDF susceptible

FTC susceptible

EFV low level resistance

L031

Virological failure

C

D67E (1.05)

F77L (1.02)

F227L (1.78)

1

TDF and FTC susceptible

EFV resistance

TDF susceptible

FTC susceptible

EFV resistance

L054

Virological failure

C

A62V (1.51)

D67E (1.16)

F77L (1.52)

F227L (1.26)

1

TDF resistance and FTC susceptible

EFV resistance

TDF resistance

FTC susceptible

EFV resistance

L064

Virological failure

C

D67E (1.32)

F227L (1.43)

1

TDF and FTC susceptible

EFV susceptible

TDF susceptible

FTC susceptible

EFV resistance

L074

Suppressed

CRF37_cpx

D67E (1.72)

T69N (1.34)

M184I (1.04)

P225H (1.12)

F227L (1.86)

1

TDF and FTC resistance

EFV resistance

TDF susceptible

FTC resistance

EFV resistance

L075

Suppressed

CRF37_cpx

D67E (1.83)

T69N (1.58)

L74V (1.23)

F77L (1.01)

M184I (1.44)

P225H (2.22)

F227L (1.47)

1

TDF and FTC resistance

EFV resistance

TDF susceptible

FTC resistance

EFV low level resistance