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Fig. 4 | Virology Journal

Fig. 4

From: Analysis of HIV-1 intersubtype recombination breakpoints suggests region with high pairing probability may be a more fundamental factor than sequence similarity affecting HIV-1 recombination

Fig. 4

Holliday junctions (HJ) that arise from BS-based copy choice. a During DNA synthesis, a BS forms between two single-stranded DNAs of the same polarity. When the BS is encountered consecutively by the two polymerases, which engage maternal and paternal DNA, respectively, it mediates two rounds of copy choice, resulting in a single HJ. b Another BS forms downstream the first HJ. When both maternal and paternal polymerases encounter a second BS, the same process of copy choice is performed as at the first BS, leading to a double-Holliday junction

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Virology Journal

ISSN: 1743-422X