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Table 2 Nucleotide and amino acid substitutions of attenuation positions in oral PV vaccine strains Sabin 3 and four PV3 isolates

From: Characterization of four vaccine-related polioviruses including two intertypic type 3/type 2 recombinants associated with aseptic encephalitis

Strain

5′UTR

VP3

VP1

 

Nucleotide (472)

Nucleotide (2034)

Amino acid (91)

Nucleotide (2493)

Amino acid (6)

Sabin 3

T

T

Phe

C

Thr

RF108

T

T

Phe

T

ILe

RF134

T

T

Phe

T

ILe

RF146

T

T

Phe

T

ILe

RF151

T

T

Phe

T

ILe

WPV3

C

C

Ser

T

ILe

  1. The nucleotide mutation position refers to the complete genome, whereas the corresponding amino acid change is numbered according to the primary amino acid sequence of a given protein after cleavage of the polyprotein precursor