Table 1 Nucleotide and amino acid substitutions identified in a mouse-adapted highly pathogenic H5N2 avian influenza virus
Segment | Nucleotide position | Nucleotide substitution | Amino acid position | Amino acid substitution | |
|---|---|---|---|---|---|
PB2 | 1879 (G → A) | Passage 2 (P2) | G | 627(E → K) | E |
P3 | G/A | E/K | |||
P4 | A | K | |||
P10 | A | K | |||
PB1 | 542 (T → C) | P7 | T | 181 (I → T) | I |
P8 | C | T | |||
P10 | C | T | |||
2103 | T → C | 701 | - | ||
2112 | A → G | 704 | - | ||
HA | 448 (G → T) | P6 | G | 150 (A → S) | A |
P7 | G/T | A/S | |||
P8 | T | S | |||
P10 | T | S | |||
NS | 678 (A → G) | P8 | A | NS1, 226 (Terminator → W) | Terminator |
NS2, 69 (E → G) | E | ||||
P9 | A/G | NS1, 226 | Terminator/(W, “WRNKVAD” was extended) | ||
NS2, 69 | E/G | ||||
P10 | G | NS1, 226 | W, “WRNKVAD” was extended | ||
NS2, 69 | G | ||||