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Fig. 2 | Virology Journal

Fig. 2

From: Amino acid substitutions involved in the adaptation of a novel highly pathogenic H5N2 avian influenza virus in mice

Fig. 2

Histology and immunohistochemistry of mice infected with the mouse-adapted H5N2 avian influenza virus. Lung pathology was determined in mice infected with mouse-adapted strain of an H5N2 avian influenza virus at 3 days post inoculation (dpi) (a). Hematoxylin and eosin staining was used to examine the histology of the lung tissue. Mice infected with the mouse-adapted virus displayed severe interstitial pneumonia in lung tissues, shown by the alveolar lumen flooded with dropout from alveolar cells, erythrocytes, and inflammatory cells (diamond); and congestion in the blood vessels (triangle). Viral nucleoprotein was detected in the lungs using immunohistochemistry in mice infected with the mouse-adapted viruses (b). Arrows indicate positively stained lung alveolar epithelial cells

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