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Table 1 Neurovirulence of mice infected with 2.3 × 105 PFU/50 μl HSV-1 wild type, MU-complemented P1 and UL7-MU strain

From: The mutated tegument protein UL7 attenuates the virulence of herpes simplex virus 1 by reducing the modulation of α-4 gene transcription

Days Groups
Wild-type MU-complemented P1 UL7-MU Negative control
CNS Spinal cord CNS Spinal cord CNS Spinal cord CNS Spinal cord
4 + + ± ± ± ± - -
6 + + + + ± ± - -
7 + + + + ± ± - -
8 + + + + ± ± - -
10 + ++ + + ± ± - -
  1. Scale as follows
  2. Grade -, normal tissue
  3. Grade+, slight infiltration of inflammatory cells without neural damage
  4. Grade++, slight neural damage with inflammatory cell infiltration
  5. Grade+++, massive neural damage with inflammatory cell infiltration
  6. Grade++++, serious neural damage with inflammatory cell infiltration