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Table 1 Neurovirulence of mice infected with 2.3 × 105 PFU/50 μl HSV-1 wild type, MU-complemented P1 and UL7-MU strain

From: The mutated tegument protein UL7 attenuates the virulence of herpes simplex virus 1 by reducing the modulation of α-4 gene transcription

Days

Groups

Wild-type

MU-complemented P1

UL7-MU

Negative control

CNS

Spinal cord

CNS

Spinal cord

CNS

Spinal cord

CNS

Spinal cord

4

+

+

±

±

±

±

-

-

6

+

+

+

+

±

±

-

-

7

+

+

+

+

±

±

-

-

8

+

+

+

+

±

±

-

-

10

+

++

+

+

±

±

-

-

  1. Scale as follows
  2. Grade -, normal tissue
  3. Grade+, slight infiltration of inflammatory cells without neural damage
  4. Grade++, slight neural damage with inflammatory cell infiltration
  5. Grade+++, massive neural damage with inflammatory cell infiltration
  6. Grade++++, serious neural damage with inflammatory cell infiltration
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Virology Journal

ISSN: 1743-422X