Skip to main content
Fig. 5 | Virology Journal

Fig. 5

From: G45R mutation in the nonstructural protein 1 of A/Puerto Rico/8/1934 (H1N1) enhances viral replication independent of dsRNA-binding activity and type I interferon biology

Fig. 5

Replication kinetics of the rX31 virus encoding PR8 NS1s (WT, G45R or R38AK41A (AA)) in wild type (WT) and type I IFN receptor null (IFNARnull) Let1 cells. rX31 with G45R replicated to significantly higher titer that WT in both a WT and b IFNARnull Let1 cells. The virus with RNA binding deficient NS1, AA, could not replicate well in both cell types. *** represents the statistically significant difference of mean titers compared to the WT at p < 0.001, as determined by ANOVA

Back to article page

Virology Journal

ISSN: 1743-422X