From: Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins
Species | NSs localization | NSs functions | Proposed mechanisms |
---|---|---|---|
RVFV | N, C | Host general transcription suppression | Sequestration of TFIIH p44 [62] |
Degradation of TFIIH p62 [64, 69] | |||
Suppression of IFN-β gene activation | Interaction with SAP30 [123] | ||
Facilitation of viral translation | Degradation of PKR [96, 97, 102, 103] | ||
Sequestration of PABP1 [111, 112] | |||
TOSV | C | Suppression of IFN-β gene activation | Degradation of RIG-I [79, 126] |
Facilitation of viral translation | Degradation of PKR [87] | ||
SFTSV | C | Suppression of IFN-β gene activation | Sequestration of TBK1/IKKε [82, 83, 132] |
Suppression of IFN-β signaling | Sequestration of STAT2 [133] | ||
Facilitation of viral replication | Virosome-like structure [81] | ||
BUNV | N, C | Host general transcription suppression | Inhibition of RNA pol-II [89, 90] |
Suppression of IFN-β gene activation | Inhibition of RNA pol-II? [135] | ||
Facilitation of viral translation | Unknown [105] | ||
LACV | N, C | Host general transcription suppression | Inhibition of RNA pol-II [93] |
Suppression of IFN-β gene activation | Inhibition of RNA pol-II? [93] | ||
Facilitation of viral translation | Unknown [106] |