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Table 1 NSs functions of RVFV and other bunyaviruses

From: Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins

Species NSs localization NSs functions Proposed mechanisms
RVFV N, C Host general transcription suppression Sequestration of TFIIH p44 [62]
    Degradation of TFIIH p62 [64, 69]
   Suppression of IFN-β gene activation Interaction with SAP30 [123]
   Facilitation of viral translation Degradation of PKR [96, 97, 102, 103]
    Sequestration of PABP1 [111, 112]
TOSV C Suppression of IFN-β gene activation Degradation of RIG-I [79, 126]
   Facilitation of viral translation Degradation of PKR [87]
SFTSV C Suppression of IFN-β gene activation Sequestration of TBK1/IKKε [82, 83, 132]
   Suppression of IFN-β signaling Sequestration of STAT2 [133]
   Facilitation of viral replication Virosome-like structure [81]
BUNV N, C Host general transcription suppression Inhibition of RNA pol-II [89, 90]
   Suppression of IFN-β gene activation Inhibition of RNA pol-II? [135]
   Facilitation of viral translation Unknown [105]
LACV N, C Host general transcription suppression Inhibition of RNA pol-II [93]
   Suppression of IFN-β gene activation Inhibition of RNA pol-II? [93]
   Facilitation of viral translation Unknown [106]
  1. N nucleus, C cytoplasm