Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins

Table 1 NSs functions of RVFV and other bunyaviruses

Species	NSs localization	NSs functions	Proposed mechanisms
RVFV	N, C	Host general transcription suppression	Sequestration of TFIIH p44 [62]
			Degradation of TFIIH p62 [64, 69]
		Suppression of IFN-β gene activation	Interaction with SAP30 [123]
		Facilitation of viral translation	Degradation of PKR [96, 97, 102, 103]
			Sequestration of PABP1 [111, 112]
TOSV	C	Suppression of IFN-β gene activation	Degradation of RIG-I [79, 126]
		Facilitation of viral translation	Degradation of PKR [87]
SFTSV	C	Suppression of IFN-β gene activation	Sequestration of TBK1/IKKε [82, 83, 132]
		Suppression of IFN-β signaling	Sequestration of STAT2 [133]
		Facilitation of viral replication	Virosome-like structure [81]
BUNV	N, C	Host general transcription suppression	Inhibition of RNA pol-II [89, 90]
		Suppression of IFN-β gene activation	Inhibition of RNA pol-II? [135]
		Facilitation of viral translation	Unknown [105]
LACV	N, C	Host general transcription suppression	Inhibition of RNA pol-II [93]
		Suppression of IFN-β gene activation	Inhibition of RNA pol-II? [93]
		Facilitation of viral translation	Unknown [106]

ISSN: 1743-422X