Fig. 3From: Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteinsSchematics of RVFV NSs-mediated PKR degradation. RVFV NSs protein forms the E3 ligase complex, which consists of CUL1, Skp1, and FBXW11. The E3 ligase complex promotes the degradation of PKR via the ubiquitin-proteasome pathway. NEDD8 activating enzyme (NAE1) can be selectively inhibited by MLN4924Back to article page