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Fig. 3 | Virology Journal

Fig. 3

From: miR-124 attenuates Japanese encephalitis virus replication by targeting DNM2

Fig. 3

miR-124 interacts with the predicted target site in the 3’UTRs of DNM2 mRNA. a Potential base pairing is indicated by vertical lines between the sequence of miR-124 (bold) and its target sequences within the 3’ UTR of DNM2 in pig, human and mouse. The DNM2 3’UTR mutants (Mut1 and Mut2), containing a mutated miR-124 binding site, are shown. b BHK-21 cells were co-transfected with luciferase reporter vectors containing the wild type or mutant 3’UTR of porcine DNM2 and the miR-124 mimic or miR-negative control. The luciferase assay was performed 24 h after the transfection. Renilla luciferase values were normalized against firefly luciferase values, **p < 0.01, NS, not significant

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