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Fig. 4 | Virology Journal

Fig. 4

From: Isolation of dengue virus serotype 4 genotype II from a patient with high viral load and a mixed Th1/Th17 inflammatory cytokine profile in South Brazil

Fig. 4

Response to type I IFN treatment. Huh7.5 cells were infected with DENV-4 TVP/360 or LRV13/422. After infection at different MOIs (from 0.001 to 0.05), the cells were treated with 100 IU/mL IFN-α 2A. * P <0.05 compared to non-treated controls (a). Additionally, Huh7.5 cells were infected at a MOI of 0.05 and treated with a range of IFN-α 2A concentrations (from 1 to 1000 IU/mL). For the IFN-α concentration response curve data were analyzed using a sigmoidal dose-response curve (variable slope). * P <0.05 between strains (b). Data were analyzed using a two-way ANOVA followed by Bonferroni’s test, and represent the means ± SD of four independent experiments

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Virology Journal

ISSN: 1743-422X