Table 5 The tables show the predicted ELMs for the coevolving residues along with the coevolving positions of amino acid residue of non-structural proteins of Chikungunya virus. The coevolving amino acid residues are written in the bracket “()”
From: Analysis of coevolution in nonstructural proteins of chikungunya virus
a: ELMs for coevolving residues in nsP1 where, | |
Position (residue) | ELMsa |
3(S) | LIG_WD40_WDR5_VDV_1, LIG_LIR_Gen_1, DEG_Nend_UBRbox_2 |
75(D) | DRK,CLV_NRD_NRD_1 |
172(V) | DOC_MAPK_1 |
176(V) | DOC_MAPK_1 |
291(M) | MOD_ProDKin_1, MOD_PKA_1, MOD_PKA_1, DOC_WW_Pin1_4 |
383(L) | LIG_SH2_STAT5 |
409(V) | DOC_CYCLIN_1 |
453(G) | MOD_GSK3_1 |
472(R) | TRG_LysEnd_APsAcLL_1,DOC_CYCLIN_1, CLV_PCSK_SKI1_1 |
485(N) | MOD_GlcNHglycan |
486(A) | MOD_GlcNHglycan |
506(H) | DEG_APCC_DBOX_1 |
517(E) | LIG_TRAF2_1 |
b: ELMs for coevolving residues in nsP2 | |
Position (residue) | Motifsb |
16(L) | MOD_GSK3_1,LIG_FHA_1 |
170(K) | LIG_SH3_1,LIG_SH3_3 |
273(L) | DOC_MAPK_1 |
338(M) | LIG_SUMO_SIM_par_1 |
463(S) | MOD_GSK3_1 |
510(K) | MOD_ProDKin_1,LIG_14-3-3_3,DOC_WW_Pin1_4 |
54(S) | LIG_Integrin_isoDGR_1 |
642(Y) | MOD_NEK2_1,MOD_GlcNHglycan |
683(V) | LIG_LIR_LC3C_4,LIG_SUMO_SIM_anti_2 |
69(V) | TRG_LysEnd_APsAcLL_1,LIG_SH3_3,LIG_eIF4E_1 |
768(S) | MOD_NEK2_1 |
c: ELMs for coevolving residues in nsP3 | |
Position (residue) | Motifsc |
122(T) | LIG_14-3-3_2,MOD_NEK2_1,MOD_PKA_2 |
132(M) | CLV_C14_Caspase3-7,MOD_GSK3_1 |
327(S) | LIG_TRAF2_1,MOD_CK1_1,MOD_CK2_1,MOD_GSK3_1,MOD_PKA_2 |
330(S) | MOD_GlcNHglycan,LIG_TRAF2_1,MOD_CK1_1,MOD_CK2_1,MOD_GSK3_1,MOD_PKA_2 |
332(Q) | MOD_GlcNHglycan,LIG_TRAF2_1,MOD_CK1_1,MOD_CK2_1,MOD_GSK3_1 |
349(V) | MOD_PLK |
361(D) | CLV_C14_Caspase3-7 |
377(H) | MOD_GSK3_1 |
378(T) | MOD_GSK3_1 |
381(S) | MOD_GSK3_1 |
395(S) | LIG_SH3_3 |
397(V) | LIG_SH3_3 |
408(R) | CLV_PCSK_SKI1_1,MOD_N-GLC_1,DOC_CYCLIN_1,DOC_MAPK_1,MOD_PKB_1,TRG_ER_diArg_1 |
411(T) | CLV_PCSK_SKI1_1,MOD_N-GLC_1,DOC_CYCLIN_1,DOC_MAPK_1,MOD_CK2_1,MOD_PKB_1 |
434(L) | DEG_APCC_DBOX_1 |
436(P) | DEG_APCC_DBOX_1 |
437(A) | DEG_APCC_DBOX_1 |
452(Q) | DOC_PP2B_LxvP_1 |
455(P) | MOD_CK2_1 |
462(N) | LIG_SH3_3,MOD_CK1_1 |
463(H) | LIG_SH3_3 |
464(P) | LIG_EVH1_2,LIG_SH3_3,MOD_GSK3_1 |
466(I) | LIG_EVH1_2,MOD_GSK3_1 |
d: ELMs for coevolving residues in nsP4 | |
Position (residue) | Motifsd |
113(V) | MOD_CK2_1,MOD_GSK3_1,MOD_PKA_2 |
137(S) | DOC_USP7_1,MOD_GSK3_1 |
15(K) | DOC_MAPK_1,MOD_GSK3_1,MOD_PKA_2 |
182(S) | LIG_14-3-3_3,MOD_CK1_1,MOD_GSK3_1 |
20(S) | DOC_MAPK_1,MOD_GSK3_1,MOD_PKA_2 |
512(H) | MOD_GSK3_1,MOD_NEK2_1 |
571(Y) | MOD_CK2_1 |
582(A) | LIG_SUMO_SIM_anti_2 |
603(V) | DOC_MAPK_1,MOD_NEK2_2 |
77(I) | LIG_Actin_WH2_2 |
79(R) | CLV_PCSK_FUR_1,DOC_MAPK_1,LIG_Actin_WH2_2 |
81(K) | CLV_PCSK_FUR_1,CLV_PCSK_PC1ET2_1,DOC_MAPK_1,LIG_Actin_WH2_2 |
90(A) | LIG_FHA_1,LIG_SH2_STAT5,LIG_SH3_3,MOD_ProDKin_1,DOC_WW_Pin1_4 |