Analysis of coevolution in nonstructural proteins of chikungunya virus

Table 3 Amino acid variations in Delhi samples in comparison with ESCA lineage and other Indian samples

a: Amino acid variations of Delhi samples in nsP1
Name of protein	Sample Site							128	253	314	376	488
CHIKV nsp1	S27- African Prototype							T	K	M	T	Q
	Andhra Pradesh							K	K	L/M	M	R
	(n = 5)
	Gujarat							K	K	L/M	M	R
	(n = 5)
	Karnataka							K	K	L	M	R
	(n = 3)
	Kerala							K	K	L/M	M	R
	(n = 9)
	Rajasthan							K	K	M	M	R
	(n = 2)
	Tamil Nadu							K	K	M	M	R
	(n = 1)
	West Bengal							T	T	M	T	Q
	(n = 1)
	Maharashtra							T/K	T/K	M	M	R
	(n = 3)
	Delhi							K	K	M	M	R
	(n = 14)
b: Amino acid variations of Delhi samples in nsP2
Name of protein	Sample Site	48	54	181	237	238	329	374	411	539	708	793
CHIKV nsp2	S27- African Prototype	V	N	V	L	L	K	H	N	L	L	A
	Andhra Pradesh	V	N	V	L	L	K	Y	N	L	L	V
	(n = 5)
	Gujarat	V	N	V	L	L	K	Y	N	L	L	V
	(n = 5)
	Karnataka	V	N	V/A	L	L	K	Y	N	L	L	V
	(n = 3)
	Kerala	A/V	N	V	R/L	P/L	E/K	Y	D/N	L/S	P/L	V
	(n = 9)
	Rajasthan	V	N	V	L	L	K	Y	N	L	L	V
	(n = 2)
	Tamil Nadu	V	N	V	L	L	K	Y	N	L	L	V
	(n = 1)
	West Bengal	V	S	V	L	L	K	H	N	L	L	A
	(n = 1)
	Maharashtra	V	S/N	V	L	L	K	H/Y	N	L	L	V/A
	(n = 3)
	Delhi	V	N	V	L	L	K	Y	N	L	L	V
	(n = 14)
c: Amino acid variations of Delhi samples in nsP3
Name of protein		Sample Site						175	217	341	353	501
CHIKV nsp3		S27- African Prototype						V	Y	T	I	L
		Andhra Pradesh						I	H	T/M	I	L
		(n = 5)
		Gujarat						I	H	T	I	S/L
		(n = 5)
		Karnataka						I	H	T	I	S/L
		(n = 3)
		Kerala						I	H	T	I	L
		(n = 9)
		Rajasthan						I	H	T	I	L
		(n = 2)
		Tamil Nadu						I	H	M	I	L
		(n = 1)
		West Bengal						V	Y	T	T	L
		(n = 1)
		Maharashtra						I/V	Y/H	T	I/T	L
		(n = 3)
		Delhi						I	H	T	I	L
		(n = 14)
d: Amino acid variations of Delhi samples in nsP4
Name of protein		Sample Site							43	85	90	235
CHIKV nsp4		S27- African Prototype							A	R	S	Q
		Andhra Pradesh							A	R	S	Q
		(n = 5)
		Gujarat							A	R	S	Q
		(n = 5)
		Karnataka							A	R	S	Q
		(n = 3)
		Kerala							A	R	S	Q
		(n = 9)
		Rajasthan							A	R	S	Q
		(n = 2)
		Tamil Nadu							A	R	S	Q
		(n = 1)
		West Bengal							L	K	A	R
		(n = 1)
		Maharashtra							L/A	K/R	A/S	R/Q
		(n = 3)
		Delhi							A	R	S	Q
		(n = 14)

ISSN: 1743-422X