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Table 2 Function of human and murine miRNAs modulated during flavivirus infection

From: A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections

Flavivirus

miRNA

Host system

Function

Reference

WNV

Hs_154

HEK293, SK-N-MC, Huh7, Huh7.5 and mouse brain

Modulates the apoptotic response

Smith et al., [120]

WNV

miR-532-5p

HEK293 and mouse brain

Suppresses genes SESTD1 and TAB3

Slonchak et al., [121]

DENV-2

miR-146a

PBMC and THP-1

Dampens IFN-β production by targeting TRAF6

Wu et al., [118]

DENV-1, 2 and 3

miR-30e*

U937, HeLa and PBMC

Up-regulates IFN-β and ISG expression

Zhu et al., [123]

DENV-2

miR-150

PMBC

Regulates SOCS1 expression

Chen et al., [126]

DEN-2

miR-223

EAhy926, HepG2 and Vero

Represses STMN1

Wu et al., [127]

DENV-2 and 4

Let-7c

Huh7

Modulates BACH1 and HO-1 expression

Escalera-Cueto et al., [124]

JEV

miR-29b

BV-2 and primary microglial cells

Microglia activation by targeting TNFAIP3

Thounaojam et al., [130]

JEV

miR-155

BV-2, mouse primary microglial cells, mouse and human brains

Inhibits SHIP1 expression and promotes IFN-β expression

Thounaojam et al., [131]

JEV

miR-155

CHME3

Represses IFN-β production

Pareek et al., [132]

JEV

miR-15b

BV-2, U251, HeLa and mouse brain

Represses RNF125, a RIG-I inhibitor

Wu et al., [127]

JEV

miR-146a

CHME3

Down-regulation of TRAF6 expression

Sharma et al., [133]

  1. Abbreviations: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1, DENV dengue virus, HO-1 haeme oxygenase-1, IFN interferon, JEV Japanese encephalitis virus, RIG-I retinoic acid-inducible gene 1, RNF125 ring finger protein 125, SESTD1 SEC14 and spectrin domains 1, SHIP1 Src homology 2-containing inositol phosphatase 1, SOCS1 suppressor of cytokine signalling 1, STMN1 stathmin 1, TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3, TNFAIP3 tumour necrosis factor alpha-induced protein 3, TRAF6 TNF receptor-associated factor 6, WNV West Nile virus
  2. Host system: BV-2 (Mouse microglial cell line), CHME3 (Human brain microglial cell line), EAhy926 (Human vascular endothelial cell line), HEK293 (Human embryonic kidney 293 cell line), HeLa (Human cervical carcinoma cell line), HepG2 (Human hepatocellular carcinoma cell line), Huh7 and Huh7.5 (Human hepatocarcinoma cell line), PBMC (Human peripheral blood mononuclear cells), SK-N-MC (Human neuroblastoma cell line), THP-1 (Human monocytic cell line), U251 cells (Human astrocytoma cell line), U937 (Human leukaemic monocyte lymphoma cell line) and Vero (African green monkey kidney cell line)