From: A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
Flavivirus | miRNA | Host system | Function | Reference |
---|---|---|---|---|
WNV | Hs_154 | HEK293, SK-N-MC, Huh7, Huh7.5 and mouse brain | Modulates the apoptotic response | Smith et al., [120] |
WNV | miR-532-5p | HEK293 and mouse brain | Suppresses genes SESTD1 and TAB3 | Slonchak et al., [121] |
DENV-2 | miR-146a | PBMC and THP-1 | Dampens IFN-β production by targeting TRAF6 | Wu et al., [118] |
DENV-1, 2 and 3 | miR-30e* | U937, HeLa and PBMC | Up-regulates IFN-β and ISG expression | Zhu et al., [123] |
DENV-2 | miR-150 | PMBC | Regulates SOCS1 expression | Chen et al., [126] |
DEN-2 | miR-223 | EAhy926, HepG2 and Vero | Represses STMN1 | Wu et al., [127] |
DENV-2 and 4 | Let-7c | Huh7 | Modulates BACH1 and HO-1 expression | Escalera-Cueto et al., [124] |
JEV | miR-29b | BV-2 and primary microglial cells | Microglia activation by targeting TNFAIP3 | Thounaojam et al., [130] |
JEV | miR-155 | BV-2, mouse primary microglial cells, mouse and human brains | Inhibits SHIP1 expression and promotes IFN-β expression | Thounaojam et al., [131] |
JEV | miR-155 | CHME3 | Represses IFN-β production | Pareek et al., [132] |
JEV | miR-15b | BV-2, U251, HeLa and mouse brain | Represses RNF125, a RIG-I inhibitor | Wu et al., [127] |
JEV | miR-146a | CHME3 | Down-regulation of TRAF6 expression | Sharma et al., [133] |