A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections

Bavia, Lorena; Mosimann, Ana Luiza Pamplona; Aoki, Mateus Nóbrega; Duarte dos Santos, Claudia Nunes

doi:10.1186/s12985-016-0541-3

Virology Journal

Table 1 Viral sfRNA and small RNA in flavivirus infection.

From: A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections

Virus	sfRNA	Small RNA^a	Host system	Function	Reference
WNV	600 nt		MEF		Scherbik et al., 2006
WNV	525 nt		BHK-21 and mice	Facilitated viral replication and viral pathogenicity	Pijlman et al., 2008
WNV	525 nt		MEF and mice	Viral evasion	Schuessler et al., 2012
WNV (replicon)			Vero, BHK-21, S2, U4.4 and Ap61	Suppression of RNAi machinery	Schnettler et al., 2012
WNV		19 – 29 nt	Culex (pipiens) quinquefasciatus		Brackney et al., 2009
WNV		19, 21 and 28 nt	DC from WT mouse, lymph node and spleen cells from IFNRab ^−/− mice	Possible involvement with IFN response	Parameswaran et al., 2010
WNV		KUN-miR-1 (21 nt)	C6/36, Aag2	Targets GATA4 mRNA	Hussain et al., 2012
DENV-2 (replicon)	400 nt		BHK-21		Pijlman et al., 2008
DENV-1 DENV-2 DENV-3 DENV-4	430 nt 180, 270, 429 nt 410 nt 390 nt		Vero, BHK-21, A549, HepG2, C6/36 and mouse brain	Possible role in viral life cycle and pathogenesis	Liu et al., 2010
DENV-2	429 nt		Vero and BHK-21	Cytopathogenicity and apoptosis	Liu et al., 2014
DENV-2			Huh7	Interference with translation of antiviral interferon-stimulated mRNAs	Bidet et al. 2014
DENV-2			Huh7 and primary monocytes	sfRNA binds TRIM25	Manokaran et al., 2015
DENV-2		17 and 22 nt	Huh.7		Parameswaran et al., 2010
DENV-2		27 nt 21 nt	C6/36 Aag2 and Aedes aegypti		Scott et al., 2010
DENV-2		13-19 nt 24–30 nt	Aedes aegypti		Hess et al., 2011
DENV-2		vsRNA-1 (22 nt) vsRNA-2 (27 nt) vsRNA-3 (20 nt) vsRNA-4 (21 nt) vsRNA-5 (23 nt) vsRNA-6 (21 nt)	Aedes aegypti Aag2, C6/36 and Vero	Regulation of RNA replication by targeting NS1 (vsRNA-5)	Hussain and Asgari, 2014
DENV-4		21 nt 12–36 nt	U4.4 Vero and Huh7		Schirtzinger et al., 2015
JEV	521 - 523 nt		BHK-21 and C6/36	Modulation of viral replication	Lin et al., 2004
JEV			BHK-21	Regulation of viral RNA replication and translation	Fan et al., 2011
JEV			BHK-21, C6/36 and A549	Inhibition of the induction of IFN-beta	Chang et al., 2013
MVEV	600 nt		Brain of infected mice (C3H/HeJ and C3H/RV) and Vero		Urosevic et al., 1997
MVEV	500 nt		BHK-21		Pijlman et al., 2008
YFV	300 nt		BHK-21		Pijlman et al., 2008
YFV	235, 330 and 630 nt 330 nt		BHK-21, Vero, SW13 C6/36		Silva et al., 2010
SRV	500 nt		BHK-21		Pijlman et al., 2008
TBEV		22 nt	IDE8		Schnettler et al., 2014
LGTV		22 nt	IDE8		Schnettler et al., 2014

Grey specifies the molecule found and the respective host system
Abbreviations: DENV Dengue virus; JEV Japanese encephalitis virus; LGTV Langat virus; MVEV Murray Valley encephalitis virus; SRV Saumarez Reef virus; TBEV Tick-borne encephalitis virus; WNV West Nile virus; YFV Yellow fever virus
Host system: A549 (Human lung carcinoma cell line), Aag2 (Aedes aegypti cell line), Ap61 (Aedes pseudoscutellaris cell line), BHK-21 (Baby hamster kidney fibroblast cell line), C6/36 (Aedes albopictus cell line), HepG2 (Human hepatocellular carcinoma cell line), Huh7 (Human hepatocarcinoma cell line), IDE8 (Ixodes scapularis-derived cell line), MEF (Mouse embryonic fibroblast cell line), S2 (Drosophila melanogaster Schneider-2 cell line), SW13 (Human adrenal carcinoma cell line), U4.4 (Aedes albopictus cell line), Vero (Kidney epithelial cells from African green monkey).
^aAll information on small RNAs and miRNAs with either no function described or functionally characterized were included

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ISSN: 1743-422X

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