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Fig. 2 | Virology Journal

Fig. 2

From: A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections

Fig. 2

Hypothetical model of flavivirus miRNA-like sRNA biogenesis. Flavivirus genomic RNA is released into the cytoplasm where viral replication and translation take place. In the cytoplasm this RNA may undergo processing by the exonuclease XRN1, which is part of the mRNA decay machinery, and generate the sfRNA. The sfRNA in turn may be further processed into a pre-miRNA-like molecule by a cytoplasmic microprocessor containing Drosha whose relocalization to the cytoplasm may take place during viral infection. The flavivirus genomic RNA or replication intermediates may also be recognized by pattern recognition receptors and activate the innate immune response system. As a consequence, viral genomic RNA can be degraded in several fragments by endo and/or exonucleases. These viral RNA fragments depending on their size and structure may either be processed by Dicer or directly incorporated into RISC. Figure by Wagner Nagib de Souza Birbeire

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