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Fig. 3 | Virology Journal

Fig. 3

From: Antibodies against Lewis antigens inhibit the binding of human norovirus GII.4 virus-like particles to saliva but not to intestinal Caco-2 cells

Fig. 3

Blockade of the NoV VLP binding to saliva from a secretor (SeSe) individual by monoclonal antibodies (mAbs) against human Lewis antigens. Microtiter plates coated with saliva were preincubated with mAbs against Lea, Leb, Lex, Ley or with a combination of Lea+x or Leb+y antigens and then the VLPs (GII.4-v0 and v2, GII.4-2006b and GI.1) were added. Graphs show the means of duplicate tests. Specific blocking of VLP binding was determined by comparing the percentage of reduction of the OD values in wells with mAbs compared to wells without mAbs. Error bars indicate standard deviations of the means

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Virology Journal

ISSN: 1743-422X