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Fig. 3 | Virology Journal

Fig. 3

From: The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways

Fig. 3

HSV modulates necroptosis signaling. HSV R1 can interact with RIP1 and RIP3 via their RHIM domains. In the natural human host, HSV R1 binding to RIP3 or/and RIP1 prevents the formation of the RIP1- RIP3 necrosome and also prevents the activation of RIP3. This effect counteracts necroptosis and promotes cell survival during HSV infection and thus facilitates efficient viral replication. In contrast, the association of R1 with RIP3, in the non-natural mouse host, drives the activation of RIP3 and necroptosis of infected cells, thereby limiting viral replication

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