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Fig. 2 | Virology Journal

Fig. 2

From: The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways

Fig. 2

Necroptosis signaling pathways. Necroptosis can be induced through multiple signaling pathways that converge on RIP3. RIP3 is activated through interaction with a RHIM-containing protein in the following pathways: RIP1 (TNF family death receptors and type I IFNRs); TRIF (TLR3/4); DAI (M45/vIRA) mutant MCMV infection); HSV R1 (HSV infection in the mouse cells). Activated RIP3 phosphorylates its substrate MLKL and this event drives MLKL oligomerization and translocation to the plasma membrane, leading to necroptosis

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