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Fig. 6 | Virology Journal

Fig. 6

From: A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host

Fig. 6

Identifications of HCV cell-associated receptors and essential host factors on HLCs. Gel electrophoresis from RT-PCR products confirmed the expression of major HCV cell-associated receptors in iPS cell, Huh7 and HLCs (a, b). The expression levels of HCV cell-associated receptors and essential host factors (claudin-1, occludin, SR-BI, CD81, ApoE, ApoB, LDL-R, miR-122 and SEC14L2) in HLCs, HepaRG and primary hepatocyte were determined using real-time RT-PCR (c). * and ** represented statistical different data with a p value <0.05 or <0.01 respectively. Cellular localization of HCV cell-associated receptors was visualized using immunofluorescent straining. HLCs were visualized for claudin-1 (d), occludin (e), SR-BI (f), CD81 (g), LDL-R (h) and ApoE (i) in comparison to those observed in human fibroblasts (j)

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