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Fig. 3 | Virology Journal

Fig. 3

From: A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host

Fig. 3

The pluripotency of human iPS cell derived from hMSCs. The iPS cells were cultured in complete medium with 20 % FBS or injected into nude mice to investigate in vitro and in vivo differentiation. The spontaneous differentiation of iPS cells appeared heterogeneous cell morphology. After staining with specific antibodies, differentiated cell positive for βIII-tubulin (ectoderm), α-smooth muscle actin (mesoderm) and α-fetoprotein (endoderm) (a). In vivo differentiation of iPS cell, histological examination of teratoma in nude mice after infected with iPS cells. The teratoma section contained various types of tissue including neural rosette (ectoderm), mesoderm-derived smooth muscle, adipose tissue, cartilage (mesoderm) and endoderm-derived gut-like epithelial (endoderm) (b)

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Virology Journal

ISSN: 1743-422X