Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer

Table 1 Correlations between STK31 methylation and the different clinicopathological features of human CCs

Clinicopathological features	N	STK31 methylation		p
Clinicopathological features	N	+	-	p
Age	148
<45		49	13	0.741
≥45		66	20
Histology	102
Squamous cell carcinoma		67	13	1.000
Adenocarcinoma		18	4
Differentiation	146
Well + Moderate		75	17	0.584
Poor		42	12
Lymph node metastasis	100
Positive		23	7	0.708
Negative		56	14
FIGO stage	119
IA1 ~ IIA2		50	14	0.617
IIB ~ IIIA		45	10
Tumor size (cm)	148
<1		40	11	0.877
≥1		75	22
HPV16/18	134
No(HPV-negative)		18	0	0.037
Yes		87	29
HPV genotyping	123
HPV16		81	19	0.711
HPV18		20	3
Squamous cell carcinoma-Ag(SCC-Ag)	80
Normal		24	4	1.000
High		45	7
Neoajuvant Chemotherapy	55
No		23	7	0.029
Yes		25	0
Neoajuvant Chemotherapy resistance	55
No		44	9	0.037
Yes		0	2

ISSN: 1743-422X