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Fig. 5 | Virology Journal

Fig. 5

From: Development of an HSV-1 neutralization test with a glycoprotein D specific antibody for measurement of neutralizing antibody titer in human sera

Fig. 5

Application of ELISPOT-NT on assessing the neutralizing antibody titers against HSV-1 in a cohort. a The overall NAbs titers of this cohort were shown as log2 (NT50). b The average NAb titers among different age groups. This cohort was divided into five age groups as shown. The differences between bars 1 and 2 (p < 0.005) and between bars 2 and 3 (p < 0.05) were statistically significant by Mann–Whitney test. In contrast, no statistically significant difference was found among bars 3, 4, 5 and 6 (p > 0.05). c The average NAb titers between males and females. The NAb titers of each sex or age group were shown in box and whiskers, which shows the minimum, first quartile, median, third quartile and maximum titer levels. d Relationship between the anti-HSV IgG level and the NAb titers of 269 serum samples. The anti-HSV-1 IgG values of this cohort were tested by commercial anti-HSV-1 IgG ELISA kit, the NAb titers were assayed by ELISPOT-NT and were shown as log2 (NT50). 10 sera from this cohort were confirmed with HSV-1 IgG negative but NAbs Positive

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