Statistical correlation of nonconservative substitutions of HIV gp41 variable amino acid residues with the R5X4 HIV-1 phenotype

Pacheco-Martínez, Elena; Figueroa-Medina, Evangelina; Villarreal, Carlos; Cocho, Germinal; Medina-Franco, José L.; Méndez-Lucio, Oscar; Huerta, Leonor

doi:10.1186/s12985-016-0486-6

Virology Journal

Table 4 Pearson’s correlation coefficients (r) for hydrophaty index in gp41 alignments of R5, X4, and R5X4 sequences^a

From: Statistical correlation of nonconservative substitutions of HIV gp41 variable amino acid residues with the R5X4 HIV-1 phenotype

		R5		X4		R5X4
Position 1	Position 2	r	p	r	p	r	p
535	619	−0.18	5.7E-06	−0.38	5.5E-04	−0.31	4.3E-03
535	636	0.26	5.7E-11	0.32	3.2E-03	0.29	6.9E-03
535	641	−0.23	8.1E-09	−0.34	1.8E-03	−0.18	5.3E-02
535	662	0.15	7.7E-05	0.36	7.9E-04	0.11	1.8E-01
535	723	−0.29	2.7E-13	−0.47	2.0E-05	−0.27	9.6E-03
535	756	−0.26	8.8E-11	−0.39	2.7E-04	−0.25	1.6E-02
602	619	−0.20	3.3E-07	−0.16	8.3E-02	−0.14	9.4E-02
602	640	−0.22	2.4E-08	−0.15	1.1E-01	−0.44	5.9E-05
602	641	−0.17	7.4E-06	−0.11	1.7E-01	−0.16	8.1E-02
602	662	0.20	9.6E-07	0.20	4.5E-02	0.22	2.1E-02
602	723	−0.22	3.3E-08	−0.10	2.1E-01	−0.40	1.8E-04
602	756	−0.18	4.2E-06	−0.25	1.5E-02	−0.34	1.2E-03
619	636	−0.28	4.3E-12	−0.38	3.6E-04	−0.28	7.6E-03
619	640	0.20	2.6E-07	0.17	7.9E-02	0.47	2.6E-05
619	641	0.20	2.2E-07	0.24	2.0E-02	0.10	1.9E-01
619	658	0.16	2.9E-05	0.21	3.6E-02	0.16	8.2E-02
619	662	−0.45	2.0E-29	−0.51	1.4E-05	−0.54	6.4E-07
619	723	0.45	6.3E-29	0.44	1.1E-04	0.45	3.8E-05
619	756	0.41	2.2E-24	0.39	4.5E-04	0.45	2.1E-05
619	841	0.25	2.5E-10	−0.03	3.8E-01	0.36	6.4E-04
636	640	−0.24	4.0E-09	−0.20	3.8E-02	−0.58	2.3E-07
636	641	−0.35	6.7E-18	−0.19	5.1E-02	−0.30	3.6E-03
636	662	0.19	1.2E-06	0.28	1.0E-02	0.21	2.8E-02
636	723	−0.53	1.7E-37	−0.42	2.0E-04	−0.28	7.6E-03
636	756	−0.48	1.4E-35	−0.31	4.0E-03	−0.23	2.3E-02
640	641	0.28	1.7E-13	0.35	1.5E-03	0.35	1.2E-03
640	662	−0.21	4.3E-08	−0.31	3.9E-03	−0.48	1.4E-05
640	723	0.35	3.3E-18	0.35	1.1E-03	0.39	3.5E-04
640	756	0.29	1.5E-12	0.16	8.8E-02	0.45	1.9E-05
641	723	0.40	1.8E-23	0.52	7.0E-06	0.23	2.6E-02
641	756	0.36	6.4E-19	0.20	3.9E-02	0.16	7.3E-02
658	662	−0.18	2.5E-06	−0.26	1.1E-02	−0.13	1.2E-01
658	723	0.26	3.2E-10	0.09	2.5E-01	−0.16	7.2E-02
658	756	0.21	3.4E-07	0.08	2.4E-01	0.16	7.2E-02
662	723	−0.45	1.5E-29	−0.42	1.5E-04	−0.49	6.9E-06
662	756	−0.40	4.6E-24	−0.45	6.0E-05	−0.44	2.7E-05
662	841	−0.36	1.5E-19	−0.12	1.3E-01	−0.23	2.2E-02
723	756	0.71	1.5E-66	0.61	1.3E-07	0.67	1.5E-09
723	841	0.20	3.0E-07	0.03	4.3E-01	0.10	2.0E-01
756	841	0.24	1.5E-09	0.07	2.8E-01	0.19	4.9E-02

^a Only correlations with a p-value less than .0001 for at least one coreceptor group are shown

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