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Table 3 Summary of results of statistical comparison between the charge of amino acid positions from R4X4 and R5 sequences

From: Statistical correlation of nonconservative substitutions of HIV gp41 variable amino acid residues with the R5X4 HIV-1 phenotype

Mann–Whitney U test

 Rank

HXB2 residue

Positiona

p (U-test)b

p (QFD = .05)c

p (QFD = .10)c

Location

  1

N

636

.0002

.00086

.0017

HR2

χ2 test

 Rank

HXB2 residue

Position

p (X 2)b

p (QFD = .05)c

p (QFD = .10)c

 

  1

N

636

.00004

.00086

.0017

HR2

  2

L

602

.00005

.0017

.0034

Loop

  3

Q

658

.0010

.0026

.0052

HR2

  4

N

809

.0050

.0034

.0068

LLP-3

  5

A

667

.0055

.0043

.0086

MPER

  6

R

841

.0078

.0052

.0104

LLP-1

  1. aResidue number is based on the sequence of HXB2 gp120
  2. bBold characters indicate positions with significant p values using QFD = .05. Normal characters indicate positions with significant p values using QFD = .1
  3. cBenjamini-Hochberg critical p values