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Table 1 Human coronavirus overview

From: Coronaviruses and the human airway: a universal system for virus-host interaction studies

Name Discovery Protein Receptor Tropism Receptor Binding Domain (RBD) References
HCoV-229E 1966 Aminopeptidase N (hAPN) Non-ciliated cells S407-547 [46, 56, 57, 103, 104]
HCoV-OC43 1967 Unknowna Ciliated cells Unknown [56, 105]
SARS-CoV 2003 Angiotensin Converting Enzyme 2 (ACE2) Ciliated cells S303-537 [13, 14, 48, 57, 106]
HCoV-NL63 2004 Angiotensin Converting Enzyme 2 (ACE2) Ciliated cells S476 -616 [16, 49, 56, 107]
HCoV-HKU1 2005 Unknownb Ciliated cells Unknown [17, 56]
MERS-CoV 2012 Dipeptyl-peptidase 4 (DPP4) Non-ciliated cells S358-588 [18, 34, 51, 108]
  1. aReceptor determinant identified as N-acetyl-9-O-acetylneuraminic acid
  2. bReceptor determinant identified as O-Acetylated Sialic acid