Coronaviruses and the human airway: a universal system for virus-host interaction studies

Table 1 Human coronavirus overview

Name	Discovery	Protein Receptor	Tropism	Receptor Binding Domain (RBD)	References
HCoV-229E	1966	Aminopeptidase N (hAPN)	Non-ciliated cells	S407-547	[46, 56, 57, 103, 104]
HCoV-OC43	1967	Unknown^a	Ciliated cells	Unknown	[56, 105]
SARS-CoV	2003	Angiotensin Converting Enzyme 2 (ACE2)	Ciliated cells	S303-537	[13, 14, 48, 57, 106]
HCoV-NL63	2004	Angiotensin Converting Enzyme 2 (ACE2)	Ciliated cells	S476 -616	[16, 49, 56, 107]
HCoV-HKU1	2005	Unknown^b	Ciliated cells	Unknown	[17, 56]
MERS-CoV	2012	Dipeptyl-peptidase 4 (DPP4)	Non-ciliated cells	S358-588	[18, 34, 51, 108]

ISSN: 1743-422X