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Fig. 1 | Virology Journal

Fig. 1

From: Coronaviruses and the human airway: a universal system for virus-host interaction studies

Fig. 1

Human airway epithelial cell culture models and HCoV receptor distribution. a: Schematic representation of human tracheobronchial cells at air-liquid interface (ALI). They form a pseudostratified epithelial layer containing different cell types. b: Schematic representation of human alveolar cells at ALI that form single squamous epithelium containing only two cells types, alveolar type I and II cells. c: Illustration of the mode of infection, release and associated cell tropism of the six human coronaviruses (HCoVs) in the human airway epithelial cell culture model. SARS-CoV, HCoV-NL63, HCoV-OC43 and HCoV-HKU1 infect ciliated cells but the receptors for HCoV-HKU1 and HCoV-OC43 are currently unknown. HCoV-229E and MERS-CoV infect non-ciliated cells using different receptors

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