Gene expression profiling of rubella virus infected primary endothelial cells of fetal and adult origin

Table 2 Differential expression of genes belonging to the GO term “sensory organ development” in HUVEC and HSaVEC following RV infection

Gene symbol	Gene title	Fold change microarray ^(a)
		HUVEC	HSaVEC
ADAMTS18	ADAM metallopeptidase with thrombospondin type 1 motif, 18	−4.89	n.s.
ALDH1A2	aldehyde dehydrogenase 1 family, member A2	−4.16	n.s.
CLN8	ceroid-lipofuscinosis, neuronal 8	−8.05	n.s.
DSCAM	Down syndrome cell adhesion molecule	−9.98	n.s.
FGFR2	fibroblast growth factor receptor 2	−10.01	5.03
FZD3	frizzled family receptor 3	−10.00	−8.56
JAG2	jagged 2	−4.86	n.s.
JAG2	jagged 2	−4.01	n.s.
MYO3A	myosin 3A	−9.46	n.s.
MYO7A	myosin 7A	−5.65	−6.17
NHS	Nance-Horan syndrome	−4.35	n.s.
NOG	noggin	−6.68	−5.04
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	−7.70	n.s.
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	−6.24	n.s.
RDH10	retinol dehydrogenase 10 (all-trans)	−9.00	n.s.
SLC25A27	solute carrier family 25, member 27	−16.78	n.s.
TNPO1	transportin 1	−7.66	n.s.
TRPM1	transient receptor potential cation channel, subfamily M, member 1	−7.72	−5.76
TSPAN12	tetraspanin 12	−4.42	n.s.

^aDisplayed are the average fold changes from three independent experiments of RV-infected cells in comparison to non-infected cells detected by the microarray that meet the selected criteria (i.e. fold change cut-off ≤ −4 and ≥ 4 and ANOVA p-value of ≤ 0.01). If a gene was detected by several different probes, all fold changes that meet the selected criteria are shown. Positions labeled n.s. where not shown to be significantly up- or down-regulated in the DNA microarray analysis

ISSN: 1743-422X