Gene expression profiling of rubella virus infected primary endothelial cells of fetal and adult origin

Table 1 Differentially expressed genes of the chemokine family

Gene symbol	Gene title	Mean fold change^(a)
Gene symbol	Gene title	HUVEC	HSaVEC
CCL2	chemokine (C-C motif) ligand 2	21.03	n.s.
CCL20	chemokine (C-C motif) ligand 20	112.23	122.14
CCL23	chemokine (C-C motif) ligand 23	4.32	4.09
CCL3, CCL3L1, CCL3L3	chemokine (C-C motif) ligand 3; chemokine (C-C motif) ligand 3-like 1; chemokine (C-C motif) ligand 3-like 3	194.09	278.09
CCL4	chemokine (C-C motif) ligand 4	231.15	972.27
CCL5	chemokine (C-C motif) ligand 5	1394.87	430.3
		1254.72	325.72
		414.38	310.81
CCL7	chemokine (C-C motif) ligand 7	115.92	n.s.
CCL8	chemokine (C-C motif) ligand 8	579.29	151.42
CX3CL1	chemokine (C-X3-C motif) ligand 1	23.37	36.99
CX3CL1	chemokine (C-X3-C motif) ligand 1	12.43	28.53
CXCL1	chemokine (C-X-C motif) ligand 1	5.59	n.s.
CXCL10	chemokine (C-X-C motif) ligand 10	4833.33	297.78
CXCL11	chemokine (C-X-C motif) ligand 11	382.38	72.25
CXCL12	chemokine (C-X-C motif) ligand 12	35.66	n.s.
CXCL12	chemokine (C-X-C motif) ligand 12	7.43	n.s.
CXCL16	chemokine (C-X-C motif) ligand 16	8.68	6.29
CXCL2	chemokine (C-X-C motif) ligand 2	28.56	4.70
		25.62	4.18
		22.74
CXCL3	chemokine (C-X-C motif) ligand 3	92.97	33.14
CXCL5	chemokine (C-X-C motif) ligand 5	44.83	15.34
		22.63	12.55
			12.1
CXCL6	chemokine (C-X-C motif) ligand 6	84.27	8.97
CXCL9	chemokine (C-X-C motif) ligand 9	41.56	88.71

^(a)Displayed are average fold change of RV-infected cells in comparison to non-infected cells detected by transcriptome analysis. In positions that are labeled n.s., the gene expression did not meet the selected criteria (i.e. fold change cut-off ≤ −4 and ≥ 4 and ANOVA p-value of ≤ 0.01). If a gene was detected by several different probes, all fold changes that meet the selected criteria are shown

ISSN: 1743-422X