Fig. 2

Common changes in cellular gene expression after RV infection in fetal and adult endothelial cells. a Displayed are the percent of genes that exhibited expression changes greater than or equal to 4-fold with an ANOVA p-value of ≤ 0.01. The percentage is based on the total amount of genes assayed. b Venn diagram showing the intersection between the up-regulated (↑), down-regulated (↓) and contra-egulated (↕) transcripts 36 h after RV infection (MOI of 10) of HUVEC and HSaVEC. c Biological process and d KEGG pathway analysis of the 392 transcripts that were affected after RV infection in both fetal and adult endothelial cells. Displayed are the ranked Bonferroni corrected p-values of significantly enriched biological processes and pathways (p ≤ 0.01). Related terms were grouped and the most significant term of the group was defined as the group leading term. Numbers at the bar represent genes (in %) from the cluster that were associated with the term