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Table 3 Distribution of amino acid changes in the full-length S protein and its different regions

From: Occult hepatitis B virus infection: influence of S protein variants

OBI group No. of residue changes/100 aaa Control group No. of residue changes/100 aaa
aa 1–226 aa 1–99 aa 100–169 aa 124–147 aa 170–226 aa 1–226 aa 1–99 aa 100–169 aa 124–147 aa 170–226
O1 2.41 2.24 0.79 1.85 4.68 C1 1.70 1.12 0.83 1.54 3.79
O2 1.37 1.01 0.75 0.44 2.77 C2 1.71 0.38 0.89 0.00 5.04
O3 1.43 1.07 0.59 0.74 3.10 C3 1.51 1.17 0.23 0.00 3.69
O4 1.92 1.57 0.79 0.69 3.90 C4 1.86 1.48 0.86 0.56 3.74
O5a 2.16 1.90 1.60 1.47 3.30 C5 1.11 0.90 0.24 0.23 2.53
O5b 1.42 1.01 0.14 0.00 3.68       
O6 2.16 1.31 1.09 1.23 4.95 C6 2.47 2.02 2.86 4.17 2.77
O7 1.13 0.39 0.56 0.00 3.12 C7 2.26 2.50 1.18 2.45 3.20
O8 1.49 1.08 0.31 0.00 3.63 C8 2.29 2.13 1.19 1.16 3.90
O9 1.73 0.81 0.57 0.00 4.74 C9 1.99 0.86 2.00 2.29 3.95
O10 1.93 0.48 1.68 0.74 4.75 C10 1.77 1.01 1.02 1.49 4.01
O11 1.37 0.40 1.29 2.08 3.16 C11 1.96 0.38 1.70 1.30 5.04
O12 1.43 0.56 0.56 0.00 4.00 C12 1.62 0.67 1.81 2.22 3.04
O13a 2.21 1.11 1.64 1.04 4.82 C13 1.23 0.79 0.24 0.23 3.22
O13b 1.47 0.67 0.48 0.00 4.09       
O14 1.44 0.51 0.71 0.00 3.95 C14 1.43 0.77 0.34 0.00 3.92
O15 2.96 1.55 2.86 3.21 5.53 C15 2.26 1.68 0.95 0.00 4.87
Median 1.49 1.01 0.75 0.69 3.95 Median 1.77 1.01 0.95 1.16 3.79
P-Value 0.461 0.623 0.428 0.307 0.546       
  1. aa 1–226 full-length region, aa 1–99 N-terminal region, aa 100–169 MHR antigenic loops, aa 124–147 “α” determinant, aa 170–226 C-terminal region; areference sequence: genotype B (GQ205440), genotype C (GQ205441)