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Table 2 Distribution of stop codon, insertion, deletion and reading frame shift mutations in the full-length S protein

From: Occult hepatitis B virus infection: influence of S protein variants

OBI group

Control group

Patient

Genotype

Na

Mutationb

Type

Site (aa)

Notec

Patient

Genotype

N

Mutationa

Type

Site (aa)

Noteb

O1

C

3

TGT → TGA

Stop

69

 

C1

B

1

TTG → TAG

Stop

209

 
 

C

4

TGG → TGA

Stop

182

        
 

C

3

AGCACGGGACCA

Deletion

117-120

STGP

       

O2

C

1

TTT

Deletion

220

F

       

O3

B

1

TGG → TAG

Stop

35

        

O5a

C

2

TGG → TAG

Stop

163

        
 

C

1

Add “T” nt638

Shift

213

        

O6

C

1

TTA → TGA

Stop

217

 

C6

B

1

Miss “G” nt606

Shift

203

 

O8

B

1

Miss “G” nt54

Shift

20

        
 

C

1

Add “T” nt607

Shift

203

        
 

C

1

Miss “G” nt54

Shift

20

        
 

C

1

Miss “T” nt240

Shift

80

        

O9

C

2

TTA → TAA

Stop

216

        
 

C

4

ACC

Insert

124-125

T

       
       

C10

C

3

AACAACAAC

Insert

116-117

TTT

        

C

2

TGG → TAG

Stop

195

 

O11

C

8

TTA → TAA

Stop

216

 

C11

C

1

AACAACAAC

Insert

116-117

TTT

 

C

1

AACAACAAC

Insert

117-118

TTT

       

O13a

B

8

TGT → TGA

Stop

107

 

C13

B

1

CAG → TAG

Stop

30

 
 

C

7

TTA → TAA

Stop

216

        

O15

C

6

TTA → TAA

Stop

216

        
  1. Shift reading frame shift, Insert insertional mutation, Deletion deletion mutation, Stop stop codon mutation
  2. a the number of clones with stop codon, insertion, deletion or reading frame shift mutations in the full-length S protein
  3. b the different types of nucleotide variation, e.g. TGT → TGA indicate the nucleotide sequence change into TGA from TGT; “AGCACGGGACCA” et al. is the nucleotide sequence of insertions or deletions; Add “T” nt638 indicate to add a base”T” after nt638 of S gene; Miss “G” nt54 indicate to miss a base”G” after nt54 of S gene
  4. c the amino acid sequence of insertions or deletions
  5. b, c Reference sequence: genotype B (GQ205440), genotype C (GQ205441)