Kinetic response of wild and mutant core codon 70 strains of HCV genotype 1b to pegylated interferon-α and ribavirin therapy

Table 2 Virological response by IL28B genotypes and HCV core protein aa70 substitutions

rs12979860	Core 70	EVR	P	SVR	P	NVR	P
CC		76/89 (85.4 %)	0.005^a	66/85 (77.7 %)	<0.001^b	13/85 (15.3 %)	0.004^a
CT		11/20 (55.0 %)	0.005^a	6/19 (31.6 %)	<0.001^b	9/19 (47.4 %)	0.004^a
	Wild type	78/88 (88.6 %)	<0.001^a	65/84 (77.4 %)	<0.001^b	10/84 (11.9 %)	<0.001^a
	Mutant	9/21 (42.9 %)	<0.001^a	7/20 (35.0 %)	<0.001^b	12/20 (60.0 %)	<0.001^a
CC	Wild type	69/76 (90.8 %)	0.003^a	61/73 (83. 6 %)	0.004^a	7/73 (9.6 %)	0.002^a
CC	Mutant	7/13 (53.9 %)	0.003^a	5/12 (41.7 %)	0.004^a	6/12 (50.0 %)	0.002^a
CT	Wild type	9/12 (75.0 %)	0.065^a	4/11 (36.4 %)	1.000^a	3/11 (27.3 %)	0.07^a
CT	Mutant	2/8 (25.0 %)	0.065^a	2/8 (25.0 %)	1.000^a	6/8 (75.0 %)	0.07^a

EVR early virological response; SVR sustained virological response; NVR non-virological response
^aFisher’s Exact Test
^bPearson Chi-Square Test

ISSN: 1743-422X