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Table 2 Virological response by IL28B genotypes and HCV core protein aa70 substitutions

From: Kinetic response of wild and mutant core codon 70 strains of HCV genotype 1b to pegylated interferon-α and ribavirin therapy

rs12979860 Core 70 EVR P SVR P NVR P
CC   76/89 (85.4 %) 0.005a 66/85 (77.7 %) <0.001b 13/85 (15.3 %) 0.004a
CT 11/20 (55.0 %) 6/19 (31.6 %) 9/19 (47.4 %)
  Wild type 78/88 (88.6 %) <0.001a 65/84 (77.4 %) <0.001b 10/84 (11.9 %) <0.001a
Mutant 9/21 (42.9 %) 7/20 (35.0 %) 12/20 (60.0 %)
CC Wild type 69/76 (90.8 %) 0.003a 61/73 (83. 6 %) 0.004a 7/73 (9.6 %) 0.002a
Mutant 7/13 (53.9 %) 5/12 (41.7 %) 6/12 (50.0 %)
CT Wild type 9/12 (75.0 %) 0.065a 4/11 (36.4 %) 1.000a 3/11 (27.3 %) 0.07a
Mutant 2/8 (25.0 %) 2/8 (25.0 %) 6/8 (75.0 %)
  1. EVR early virological response; SVR sustained virological response; NVR non-virological response
  2. aFisher’s Exact Test
  3. bPearson Chi-Square Test