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Table 1 Profile of study patients and baseline clinical features

From: Kinetic response of wild and mutant core codon 70 strains of HCV genotype 1b to pegylated interferon-α and ribavirin therapy

Characteristic 70R 70Q/H P
Demographic data    
 Number 89 23  
 Gender (M/F) 52/37 12/11 0.589a
 Age (years) 44.8 (8.9) 46.9 (11.0) 0.344b
 History of blood transfusionc 40 (44.9 %) 12 (52.2 %) 0.535a
Laboratory data    
 Serum alanine aminotransferase (IU/L) 57.5 (24.6) 56.5 (20) 0.867b
 Serum aspartate aminotransferase (IU/L) 40.3 (16.9) 37.9 (16.0) 0.540b
 Total serum bilirubin (μmol/L) 17.0 (9.1) 18.6 (12.1) 0.476b
 Serum albumin (g/L) 39.6 (5.7) 38.0 (6.1) 0.241b
 γ-Glutamyl transpeptidase (IU/L) 41.9 (18.0) 40.3 (21.4) 0.725b
 Triglycerides (mmol/L) 1.1 (0.5) 1.0 (0.49) 0.427b
 Total cholesterol (mmol/L) 4.4 (0.57) 4.4 (0.71) 0.934b
 Prothrombin time (INR) 1.01 (0.18) 1.04 (0.24) 0.495b
 Prothrombin activity (%)d 91.4 (15.9) 86.3 (16.7) 0.178b
 Leukocyte count (109/L) 4.75 (1.48) 4.17 (1.0) 0.082b
 Platelet count ( 109/L) 154.2 (66.2) 140.2 (72.4) 0.379b
 Hemoglobin (g/L) 135.7 (17.1) 129.8 (22.8) 0.172b
 HCV RNA level (log10 IU/mL) 6.31 (0.66) 6.28 (0.86) 0.873b
IL28B genotype    
 rs12979860 77CC/12CT 15CC/8CT 0.038e
 rs8099917 78TT/11TG 15TT/8TG 0.025e
  1. Normal reference ranges: 5–40 IU/L for alanine aminotransferase; 8–40 IU/L for aspartate aminotransferase; 5–20 μmol/L for total serum bilirubin; 36–55 g/L for serum albumin; 10–50 IU/L for γ-Glutamyl transpeptidase; 0.22–1.69 mmol/L for triglycerides; 3.9–5.7 mmol/L for cholesterol; 0.8–1.5 INR for prothrombin time; 80–120 % for prothrombin activity; 4–10 × 109/L for leukocyte count; 100–300 × 109/L for platelet count; 110–160 g/L for hemoglobin
  2. aPearson Chi-Square Test
  3. bIndependent-Samples T Test
  4. Data are the mean (standard deviation) values, except those denoted by c, which represent the number (percentage) of patients
  5. dProthrombin activity (PTA) was calculated by the patient prothrombin time (PPT) and control prothrombin time (CPT) according to the following formula: PTA = [CPT-(CPT × 0.6)]/[PPT-(CPT × 0.6)] × 100 %
  6. eContinuity Correction Chi-Square Test