Kinetic response of wild and mutant core codon 70 strains of HCV genotype 1b to pegylated interferon-α and ribavirin therapy

Table 1 Profile of study patients and baseline clinical features

Characteristic	70R	70Q/H	P
Demographic data
Number	89	23
Gender (M/F)	52/37	12/11	0.589^a
Age (years)	44.8 (8.9)	46.9 (11.0)	0.344^b
History of blood transfusion^c	40 (44.9 %)	12 (52.2 %)	0.535^a
Laboratory data
Serum alanine aminotransferase (IU/L)	57.5 (24.6)	56.5 (20)	0.867^b
Serum aspartate aminotransferase (IU/L)	40.3 (16.9)	37.9 (16.0)	0.540^b
Total serum bilirubin (μmol/L)	17.0 (9.1)	18.6 (12.1)	0.476^b
Serum albumin (g/L)	39.6 (5.7)	38.0 (6.1)	0.241^b
γ-Glutamyl transpeptidase (IU/L)	41.9 (18.0)	40.3 (21.4)	0.725^b
Triglycerides (mmol/L)	1.1 (0.5)	1.0 (0.49)	0.427^b
Total cholesterol (mmol/L)	4.4 (0.57)	4.4 (0.71)	0.934^b
Prothrombin time (INR)	1.01 (0.18)	1.04 (0.24)	0.495^b
Prothrombin activity (%)^d	91.4 (15.9)	86.3 (16.7)	0.178^b
Leukocyte count (10⁹/L)	4.75 (1.48)	4.17 (1.0)	0.082^b
Platelet count ( 10⁹/L)	154.2 (66.2)	140.2 (72.4)	0.379^b
Hemoglobin (g/L)	135.7 (17.1)	129.8 (22.8)	0.172^b
HCV RNA level (log10 IU/mL)	6.31 (0.66)	6.28 (0.86)	0.873^b
IL28B genotype
rs12979860	77CC/12CT	15CC/8CT	0.038^e
rs8099917	78TT/11TG	15TT/8TG	0.025^e

Normal reference ranges: 5–40 IU/L for alanine aminotransferase; 8–40 IU/L for aspartate aminotransferase; 5–20 μmol/L for total serum bilirubin; 36–55 g/L for serum albumin; 10–50 IU/L for γ-Glutamyl transpeptidase; 0.22–1.69 mmol/L for triglycerides; 3.9–5.7 mmol/L for cholesterol; 0.8–1.5 INR for prothrombin time; 80–120 % for prothrombin activity; 4–10 × 10⁹/L for leukocyte count; 100–300 × 10⁹/L for platelet count; 110–160 g/L for hemoglobin
^aPearson Chi-Square Test
^bIndependent-Samples T Test
Data are the mean (standard deviation) values, except those denoted by ^c, which represent the number (percentage) of patients
^dProthrombin activity (PTA) was calculated by the patient prothrombin time (PPT) and control prothrombin time (CPT) according to the following formula: PTA = [CPT-(CPT × 0.6)]/[PPT-(CPT × 0.6)] × 100 %
^eContinuity Correction Chi-Square Test

ISSN: 1743-422X