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Fig. 2 | Virology Journal

Fig. 2

From: Kinetic response of wild and mutant core codon 70 strains of HCV genotype 1b to pegylated interferon-α and ribavirin therapy

Fig. 2

Dynamic changes in 70R and 70Q/H levels before and during PEG-IFNα/RBV treatment. a. Viral loads of 70R and 70Q/H strains (Log10 copies/mL). b. Percentage of 70R and 70Q/H strains (%). A1/B1: Patient 42 with dominant 70R achieved EVR (rs12979860 CC genotype). A2/B2: Patient 99 with dominant 70R had no response to treatment (rs12979860 CT genotype). A3/B3: Patient 9 with dominant 70Q/H had no response to treatment (rs12979860 CC genotype). A4/B4: Patient 21 with dominant 70Q/H achieved EVR but experienced breakthrough during treatment (rs12979860 CC genotype). A5/B5: Patient 106 with dominant 70R achieved EVR but discontinued therapy due to adverse events at weeks 19 and relapsed quickly (rs12979860 CC genotype). A6/B6: Patient 60 with dominant 70R achieved EVR (rs12979860 CC genotype). A7/B7: Patient 25 with dominant 70R achieved EVR (rs12979860 CT genotype)

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Virology Journal

ISSN: 1743-422X