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Table 1 Summary of patient characteristics and virological findings

From: Mechanisms downstream of reverse transcription reduce serum levels of HBV DNA but not of HBsAg in chronic hepatitis B virus infection

  HBeAg+ n = 16 HBeAg– n = 68 P value
Age, years, median, (range) 27 (16–60) 34 (18–59) 0.02
Gender (M/F) 11/5 40/28 0.57
Genotype (A/B/C/D) 3/4/2/7 15/7/3/43
Serum HBV DNAa 8.30 ± 0.38 4.30 ± 0.14 <0.0001
Serum HBsAgb 4.40 ± 0.18 3.41 ± 0.11 <0.0001
HBV DNA/HBsAg 3.90 ± 0.29 0.89 ± 0.14 <0.0001
ALT/ULN, median, (range) 1.37 (0.68–8.6) 0.72 (0.24–12.38) <0.001
cccDNAc −0.70 ± 0.20 −2.67 ± 0.10 <0.0001
S RNAc/cccDNAc 1.65 ± 0.20 2.73 ± 0.11 <0.0001
pgRNAc/cccDNAc 2.04 ± 0.12 1.50 ± 0.11 <0.01
pgRNAc/S RNAc 0.39 ± 0.23 −1.22 ± 0.07 <0.0001
  1. Virological values as mean ± SEM. P values by Mann-Whitney U test for age and ALT, t test for virological parameters and Fisher’s exact test for gender
  2. alog10 cp/mL
  3. blog10 IU/mL
  4. clog10 copies/cEq (cell equivalent), ALT/Upper Limit of Normal