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Fig. 2 | Virology Journal

Fig. 2

From: Matrix-M™ adjuvation broadens protection induced by seasonal trivalent virosomal influenza vaccine

Fig. 2

Survival proportion of homologous challenged mice. Mice (6 or 10/group) were immunized once with different doses of seasonal trivalent virosomal influenza vaccine (TVV) with or without Matrix-M™ or PBS and challenged with vaccine-homologous virus strains H1N1 A/Netherlands/602/09, H3N1 A/Perth/16/09 or B/Malaysia/2506/04 and monitored for 21 days for survival, body weight loss and clinical symptoms (Additional file 2: Figure S1). Graphs represent Kaplan-Meier survival curves. The HA amino acid sequences of H1N1 A/Netherlands/602/09 and H1N1 A/California/07/09 differ by 5 residues (99.5 % homology), those of H3N2 A/Perth/16/09 and H3N2 A/Victoria/210/09 differ by 7 residues (98.8 % homology), and those of B/Malaysia/2506/04 and B/Brisbane/60/08 differ by 5 residues (99.2 % homology) (Additional file 4: Figure S3, Additional file 5: Figure S4, Additional file 6: Figure S5)

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