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Fig. 2 | Virology Journal

Fig. 2

From: Herpes simplex virus 1 UL41 protein abrogates the antiviral activity of hZAP by degrading its mRNA

Fig. 2

HSV-1 UL41 protein inhibits the expression of hZAP. a HEK 293 T cells were co-transfected with hZAPS-Myc plasmid along with increasing amounts of UL41-Flag plasmid. 24 h after transfection, cells were lysed and the samples were then subjected to WB analysis. The lower panel presented relative density analysis of hZAPS. b and c 293Trex-hZAPL cells and 293Trex-hZAPS cells were infected with WT HSV-1 or R2621 at an MOI of 0.1, 1 or 10, respectively. At 2 h post-infection, cells were mock treated or treated with tetracycline (1000 ng/mL). Cells were lysed and the samples were subjected to WB analysis 36 h post-infection. The relative density analysis of hZAPL and hZAPS were under the WB results, respectively. One representative of three independent experiments was shown

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