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Table 1 Comparison of bat coronaviruses with SARS-CoV or MERS-CoV in conserved replicase domains and structural proteins

From: Bat origin of human coronaviruses

CoV strain Bat species Country % amino acid sequence identitya with SARS-CoV or MERS-CoV
ADRP 3CLpro RdRp Hel ExoN NendoU OMT Concatenated domains@ S E M N
HKU3 Rhinolophus sinicus China 92.0 99.3 98.6 99.2 98.1 98.0 98.3 96.0 79.7 100 98.6 96.7
Rp3 Rhinolophus sinicus China 95.4 99.7 99.5 99.7 99.2 97.4 98.3 97.7 80.3 100 97.3 98.1
Rm1 Rhinolophus macrotis China 91.0 99.3 99.3 99.3 97.9 97.1 98.0 95.6 80.6 98.7 97.3 97.6
Rf1 Rhinolophus ferrumequinum China 92.3 99.7 98.6 99.5 97.9 97.7 96.3 96.0 78.4 96.1 97.7 95.5
Rs672 Rhinolophus sinicus China 97.0 99.3 99.8 99.3 99.1 98.6 99.0 98.4 80.2 100 98.6 98.6
Rs3367 Rhinolophus sinicus China 97.0 100 99.6 99.8 99.2 98.3 98.0 98.4 92.3 100 98.2 100
RsSHC014 Rhinolophus sinicus China 96.9 99.7 99.6 99.8 99.2 98.8 97.7 98.4 90.0 98.7 98.2 99.5
WIV1 Rhinolophus sinicus China 97.0 99.7 99.5 99.8 99.2 98.8 98.0 98.4 92.2 100 98.2 99.8
Cp/Yunnan 2011 Chaerephon plicata China 97.6 100 99.1 98.5 98.1 98.6 97.3 98.2 81.1 100 99.1 98.1
Rp/Shaanxi 2011 Rhinolophus pusillus China 93.5 100 99.2 99.7 98.9 97.7 99.0 96.9 81.1 97.4 96.8 98.1
YNLF_31C Rhinolophus ferrumequinum China 97.2 99.7 99.6 99.7 99.4 98.3 97.7 98.4 79.2 100 98.6 98.3
BM48-31 Rhinolophus blasii Bulgaria 76.8 94.4 98.0 98.1 95.6 91.9 91.6 88.3 75.9 92.1 91.4 88.5
HKU4-1 Tylonycteris pachypus China 55.5 81 89.8 92.1 85.4 76 82.8 78.4 67 56.1 79 65.8
HKU5-1 Pipistrellus abramus China 56.4 82.6 91.8 93.8 91.7 79.7 85.7 80.1 64 53.6 79 61.4
NeoCoV Neoromica capensis South Africa 86.7 96.7 98 98.4 98.2 94.1 96.3 95 64 87.7 94.2 91
SC2013 Vespertilio superans China 53.5 79 88.5 93.4 85.6 76.6 88.1 85.7 69 84.5 84.7 74.4
  1. aCalculated with MEGA5.1 using a pairwise deletion option; Bat SL-CoVs are listed in the upper part of the table while camel MERS-CoV and bat CoVs related to MERS-CoV in the lower part
  2. @Seven domains were series connected and calculated with MEGA5.1 using a pairwise deletion option
  3. ADRP, ADP-ribose 1-phosphatase; 3CLpro, coronavirus NSP5 protease; RdRp RNA-dependent RNA polymerase; Hel, helicase; ExoN, exoribonuclease; NendoU, endoribonuclease; OMT, 2’-O-methyltransferase
  4. GenBank accession numbers: Tor2, NC_004718; HKU3, DQ022305; Rp3, DQ071615; Rm1, DQ412043; Rf1, DQ412042; Rs672, FJ588686; Rs3367, KC881006; RsSHC014, KC881005; WIV1, KF367457; Cp/Yunnan2011, JX993988; Rp/Shaanxi2011, JX993987; YNLF_31C, KP886808; EMC/2012, JX869059; HKU5-1, NC_009020; HKU4-1, NC_009019; BetaCoV/SC2013, KJ473821; NeoCoV, KC869678