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Table 1 A selected virus entry gene list from the parallel genome-wide RNAi screen

From: A parallel genome-wide RNAi screening strategy to identify host proteins important for entry of Marburg virus and H5N1 influenza virus

  siRNA #1 siRNA #2 siRNA #3
Gene Virus scorea rzscoreb score rzscore score rzscore
NPC1 MARV 0.32 −3.25 0.29 −3.35 0.22 −3.73
AIV 1.37 1.28 1.16
EXT1 MARV 0.22 −3.48 0.36 −2.98 0.87 −0.07
AIV 1.03 1.35 0.89
VPS16 MARV 0.26 −1.74 0.36 −2.31 0.11 −4.93
AIV 0.57 1.01 0.96
CTSL MARV 0.90 1.09 0.38 −1.82 0.11 −3.92
AIV 0.55 0.86 0.61
TIM1 MARV 2.06 1.21 1.33 −0.2 1.75 0.44
AIV 1.18 1.44 1.42
FOLR1 MARV 1.68 −0.33 0.57 0.46 0.45 0.36
AIV 1.93 0.46 0.38
ARCN1 MARV 1.17 4.71 0.03 −6.62 0.22 3.35
AIV 0.14 0.57 0.05
ATP6V0C MARV 0.27 1.32 0.11 2.03 0.26 3.53
AIV 0.15 0.04 0.05
ATP6V0D1 MARV 0.08 1.05 0.23 −1.59 0.04 3.93
AIV 0.05 0.47 0.23
ATP6AP1 MARV 0.16 0.80 0.57 −1.14 0.8 6.31
AIV 0.11 0.95 0.05
  1. For each gene, three siRNAs are shown with their robust z-score of relative infection index. siRNAs with positive values are putative influenza H5N1 virus specific host factors; siRNAs with negative values are putative Marburg virus specific host factors
  2. ascore is normalized luciferase signal by plate median signal
  3. brzscore is the robust zscore of relative infection index (log2RatioMARV/AIV)