Virology Journal

Table 1 A selected virus entry gene list from the parallel genome-wide RNAi screen

From: A parallel genome-wide RNAi screening strategy to identify host proteins important for entry of Marburg virus and H5N1 influenza virus

		siRNA #1		siRNA #2		siRNA #3
Gene	Virus	score^a	rzscore^b	score	rzscore	score	rzscore
NPC1	MARV	0.32	−3.25	0.29	−3.35	0.22	−3.73
NPC1	AIV	1.37	−3.25	1.28	−3.35	1.16	−3.73
EXT1	MARV	0.22	−3.48	0.36	−2.98	0.87	−0.07
EXT1	AIV	1.03	−3.48	1.35	−2.98	0.89	−0.07
VPS16	MARV	0.26	−1.74	0.36	−2.31	0.11	−4.93
VPS16	AIV	0.57	−1.74	1.01	−2.31	0.96	−4.93
CTSL	MARV	0.90	1.09	0.38	−1.82	0.11	−3.92
CTSL	AIV	0.55	1.09	0.86	−1.82	0.61	−3.92
TIM1	MARV	2.06	1.21	1.33	−0.2	1.75	0.44
TIM1	AIV	1.18	1.21	1.44	−0.2	1.42	0.44
FOLR1	MARV	1.68	−0.33	0.57	0.46	0.45	0.36
FOLR1	AIV	1.93	−0.33	0.46	0.46	0.38	0.36
ARCN1	MARV	1.17	4.71	0.03	−6.62	0.22	3.35
ARCN1	AIV	0.14	4.71	0.57	−6.62	0.05	3.35
ATP6V0C	MARV	0.27	1.32	0.11	2.03	0.26	3.53
ATP6V0C	AIV	0.15	1.32	0.04	2.03	0.05	3.53
ATP6V0D1	MARV	0.08	1.05	0.23	−1.59	0.04	3.93
ATP6V0D1	AIV	0.05	1.05	0.47	−1.59	0.23	3.93
ATP6AP1	MARV	0.16	0.80	0.57	−1.14	0.8	6.31
ATP6AP1	AIV	0.11	0.80	0.95	−1.14	0.05	6.31

For each gene, three siRNAs are shown with their robust z-score of relative infection index. siRNAs with positive values are putative influenza H5N1 virus specific host factors; siRNAs with negative values are putative Marburg virus specific host factors
^ascore is normalized luciferase signal by plate median signal
^brzscore is the robust zscore of relative infection index (log₂Ratio_MARV/AIV)

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