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Fig. 1 | Virology Journal

Fig. 1

From: Interleukin-27 ameliorates coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells

Fig. 1

Expression kinetics of IL-27 and IL-27R in VMC. Male BALB/c mice were infected with 103 TCID50 of CVB3 at day 0. a Body weight was monitored daily until day 10 post-infection. b The severity of myocarditis was scored every 2 days until day 10 post-infection using a scale based on foci of mononuclear infiltration and myocardial necrosis. c The myocarditis viral replication (positive strand of CVB3) and the viral loads (negative-strand of CVB3) were detected using qRT-PCR. d The survival rate of CVB3-infected mice and control mice after CVB3 infection were recorded (n = 20 per group). The expression of IL-27 in serum (e) and cardiac tissue (f) were monitored every two days until day 10 post-infection by ELISA assay. The expression of IL-27R mRNA (g) and protein (h) levels in cardiac tissue on day 7 post infection. Data are showed as the means ± SEM, Each time point contained three mice. *** P<0.001

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