Fig. 6
From: Central memory CD4+ T cells are preferential targets of double infection by HIV-1
SAMHD1-mediated restriction of HIV infection in naïve CD4+ T cells does not account for the differential distribution of naïve (TN), central memory (TCM), and effector memory (TEM) subsets among singly (EGFP+ or mC+) and doubly infected (EGFP+ mC+) cells. a Bypassing SAMHD1-mediated regulation of intracellular nucleotide pools via addition of exogenous dNs increased the representation of naïve CD4+ cells in singly and doubly infected cell populations, indicating that SAMHD1 restricts HIV-1 infection to a greater extent in naïve cells compared to memory cells. b Addition of exogenous dNs did not eliminate the under-representation of naïve T cells among doubly infected cells compared to singly infected cells (p = 0.002). c A patient with sequence-confirmed mutations in samhd1 also demonstrated increased contribution of TCM cells and decreased contribution of TN cells to the doubly infected cell population