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Table 2 Chemokine and cytokine concentrations in individual samples studied

From: Serum levels of inflammatory cytokines in Rift Valley fever patients are indicative of severe disease

Sample ID Patient gender Day post onset Disease outcome IL-8/ CXCL8 pg/ml IL-1βpg/ml IL-6 pg/ml IL-10 pg/ml TNF pg/ml IL-12p70 pg/ml CCL5/ RANTES pg/ml CXCL9/ MIG pg/ml CCL2/ MCP-1 pg/ml CXCL10/ IP-10 pg/ml Comments
SPU100/10 M 8 Fatal 735.5 18.3 6526.7 592.4 18.3 13.2 317.9 21788.6 49430.5 25448.3 Hemorrhagic
SPU105/10 M 10 Fatal 1486.7 5.4 379.0 96.3 0.0 0.0 665.1 31437.1 33042.3 23176.3 Hemorrhagic
SPU59/10 M 0 Fatal 10046.3 22.0 8956.6 161.0 7.5 0.0 368.6 19185.9 13389.9 27393.0 Hemorrhagic
SPU97/10 M 7 Fatal 15565.7 12.2 54005.5 915.6 2.3 0.0 486.9 1027.3 11008.3 18799.8 Hemorrhagic
SPU86/10 M 5 Fatal 321.8 2.8 321.2 380.8 6.1 0.0 6249.8 7535.9 6135.8 24694.0 No hemorrhagic syndrome
SPU126/10 F 3 Fatal 1312.9 10.1 1371.7 67.9 9.7 0.0 610.4 2612.9 1176.5 28142.4 Sindbis IgM positive
SPU162/10 F 2 Fatal 585.2 7.0 949.5 83.4 0.0 0.0 285.0 4225.8 758.7 28142.4 Hemorrhagic
SPU115/10 M 0 Fatal 658.7 5.9 476.7 1180.0 0.0 0.0 1325.0 8430.9 1311.4 28335.1  
SPU68/10 M 5 Fatal 193.3 5.6 44.0 16.2 34.8 0.0 114.1 1696.1 529.3 25276.2 Hemorrhagic
SA1372/10 M 3 Fatal 1298.1 5.2 300.9 138.4 5.2 5.2 324.7 8670.0 700.1 12711.7 Hemorrhagic, Sindbis IgM positive
SA1151/10 M 8 Fatal 3320.7 27.7 4873.1 60.6 2.6 5.7 506.2 34137.3 15978.6 21704.5 Hemorrhagic
SA1457/10 M 6 Fatal 385.3 0.0 454.6 110.8 0.0 6.2 2320.6 2790.1 561.5 3829.0 Hemorrhagic; Encephalitis; HIV status unknown
SA979/10 F 7 Fatal 1524.6 7.3 783.2 5.4 0.0 2.2 457.5 2910.1 747.6 766.1 Normal liver enzymes; Hemorrhagic; Sindbis IgM positive
SA1598/10 F 8 Fatal 782.4 4.6 152.7 6.5 0.0 6.2 6043.0 916.4 172.1 323.9 HIV+; encephalitis only; Normal liver enzymes; No hemorrhagic syndrome
SA744/10 M 2 Fatal 433.0 0.0 160.3 28.7 2.2 5.0 367.9 4522.6 1430.6 20833.0 Hemorrhagic; Sindbis IgM positive
SA868/10 M 1 Fatal 543.0 0.0 29.0 133.7 0.0 6.4 7131.7 1429.9 511.8 21451.2  
SA486/10 M 3 Fatal 13809.7 21.1 14055.9 126.0 2.4 7.4 1013.1 56734.4 22156.8 19544.4  
SA1325/10 M 8 Fatal 6503.5 6.8 940.1 173.2 2.7 6.0 4679.1 28687.8 27127.3 20772.2  
SA1448/10 F 5 Fatal 261.8 0.0 39.7 12.0 0.0 5.1 15101.6 392.6 93.6 132.2 Sindbis IgM positive
MEDIAN RESULTS IN FATAL CASES 782.4* 5.9 476.7 110.8*,** 2.3 5.0 610.4***,**** 4522.6*,** 1311.4* 21451.2*,**  
SA342/11 M 0 Survivor 303.7 2.6 18.4 0.0 2.3 0.0 24828.0 105.6 1564.9 2754.1 Hospitalized
SA257/10 M 2 Survivor 73.6 0.0 11.9 5.8 0.0 0.0 16970.3 256.3 788.9 5744.4 Hospitalized; Sindbis IgM positive
SA591/10 M 0 Survivor 69.3 2.7 25.8 0.0 0.0 0.0 4397.4 110.7 4934.3 2100.1 Hospitalized
SA921/10 M 1 Survivor 34.0 8.1 27.6 0.0 0.0 0.0 13747.7 236.0 3330.9 17652.1 Hospitalized
SA1601/10 M 7 Survivor 184.0 9.8 967.3 15.1 0.0 0.0 4258.0 84.2 1136.9 668.8 Hospitalized
SA1329/10 M 0 Survivor 150.2 2.8 47.8 0.0 0.0 0.0 3686.7 300.1 13904.5 10918.3 Hospitalized
SPU079/10 M 0 Survivor 295.7 0.0 32.2 0.0 3.2 3.2 6099.1 196.8 353.9 729.3 Hospitalized; WNV and Sindbis IgM positive
SA287/10 M 1 Survivor 3764.8 102.7 3403.8 10.8 171.8 2.4 9180.2 486.3 11250.4 15232.2 Hospitalized
SA226/10 M 2 Survivor 1844.0 19.4 864.8 0.0 58.4 2.7 6815.2 330.6 856.5 3805.3 Hospitalized
SA276/10 M 1 Survivor 1341.5 8.1 370.1 6.7 5.0 0.0 4776.0 329.6 8724.8 7047.2 Hospitalized
SA918/10 M 2 Survivor 4657.3 36.9 8.0 0.0 0.0 0.0 12142.9 203.1 1695.4 614.6 Hospitalized
SA399/10 M 0 Survivor 265.7 0.0 51.4 32.5 0.0 2.8 7936.6 307.3 5832.6 17407.5 Hospitalized
SPU062/10 M 3 Survivor 132.7 3.0 127.8 6.7 0.0 0.0 17843.0 247.2 3465.7 10816.4  
SA165/10 F 3 Survivor 115.9 0.0 10.5 0.0 0.0 0.0 6680.6 104.0 325.9 2923.9 Sindbis IgM positive
SA197/10 M 13 Survivor 296.0 7.6 309.8 70.2 0.0 0.0 4570.4 7520.5 9217.3 17978.2  
SA472/10 M 7 Survivor 499.6 9.4 314.3 0.0 0.0 0.0 8316.3 224.0 3069.1 5206.3 SIndbis IgM positive
SA538/10 M 5 Survivor 54.2 4.9 79.3 0.0 0.0 0.0 10259.9 119.9 2392.9 3561.4  
SA746/10 M 4 Survivor 10789.3 202.8 3228.9 0.0 0.0 0.0 16001.6 138.9 4062.4 1010.0  
SA982/10 F 0 Survivor 469.1 14.9 179.8 13.6 0.0 0.0 16421.8 368.5 3479.0 8817.0  
SA1098/10 M 1 Survivor 41.6 9.0 9.6 0.0 0.0 0.0 18602.3 158.4 238.0 3599.2  
SA327/11 F 2 Survivor 1893.6 8.8 17.2 0.0 0.0 0.0 12504.9 254.7 729.4 2622.1  
SA250/10 M 1 Survivor 77.4 0.0 25.7 0.0 0.0 0.0 6213.1 79.0 490.3 918.4  
SA317/10 M 2 Survivor 148.8 5.8 48.1 0.0 0.0 0.0 5102.8 92.0 449.0 2365.6  
SA093/10 M 2 Survivor 166.3 2.7 26.6 0.0 2.2 0.0 8480.4 372.3 2214.5 10447.3  
SA128/10 M 1 Survivor 20.3 0.0 40.3 0.0 0.0 0.0 19184.5 226.6 2179.7 8363.5  
SA296/10 M 0 Survivor 121.2 5.1 94.2 0.0 0.0 5.5 5810.2 216.9 1849.5 1286.1  
SA325/10 M 2 Survivor 256.8 0.0 9.1 0.0 0.0 4.9 7534.2 135.3 772.8 2357.4  
SA1402/10 M 0 Survivor 136.1 0.0 53.4 0.0 0.0 3.2 5295.1 289.9 4027.0 8440.0  
SPU085/10 M 0 Survivor 175.5 0.0 26.8 0.0 0.0 2.7 8815.6 104.6 1520.0 2786.1  
SPU129/10 M 3 Survivor 171.2 5.5 22.4 0.0 0.0 0.0 19191.9 461.4 626.6 4289.8  
SA139/10 M 2 Survivor 97.9 0.0 17.4 0.0 0.0 5.3 14600.1 217.2 1064.3 4000.9 WN and Sindbis IgM positive
SA494/11 M 3 Survivor 51.5 0.0 7.4 0.0 0.0 2.6 19758.2 85.0 553.5 832.6  
SA523/11 M 5 Survivor 36647.8 921.1 3744.2 0.0 2.7 3.3 19391.7 101.1 539.4 900.0  
MEDIAN RESULTS IN SURVIVORS 171.2* 4.9 40.3 0.0 0.0 0.0 8815.6 217.2 1695.4* 3599.2*  
SPU332/10/28 M N/A Control 14.5 6.0 5.7 0.0 0.0 0.0 4606.7 63.2 213.7 9.3  
SPU332/10/9 F N/A Control 37.7 0.0 6.9 0.0 0.0 0.0 15593.2 638.6 219.3 135.2  
SPU332/10/27 M N/A Control 46.8 6.2 13.1 0.0 0.0 0.0 17658.3 2179.3 501.1 368.2  
SPU332/10/11 F N/A Control 218.1 8.9 5.8 0.0 0.0 0.0 15274.5 31.2 37.4 0.0  
SPU332/10/2 M N/A Control 202.8 0.0 21.2 0.0 0.0 2.2 14419.2 843.8 601.2 196.2  
SPU332/10/6 M N/A Control 28.5 0.0 0.0 0.0 0.0 2.2 24540.3 132.2 45.9 24.0  
SPU332/10/8 F N/A Control 37.2 5.0 7.5 0.0 0.0 4.8 17996.2 227.5 20.5 19.3  
SPU332/10/25 M N/A Control 9.5 0.0 0.0 0.0 0.0 2.4 54.8 0.0 0.0 0.0  
MEDIAN RESULTS IN CONTROLS 37.5 2.5 6.4 0.0 0.0 1.1 15433.8 179.8 129.8 21.6  
  1. * denotes statistical significant increase relative to results in controls (p < 0.01)
  2. ** denotes statistical significant increase relative to results in survivors (p < 0.01)
  3. *** denotes statistical significant decrease relative to results in controls (p < 0.01)
  4. **** denotes statistical significant decrease relative to results in survivors (p < 0.01)
  5. Note: because of the 1:4 dilution of serum for the cytokine analysis, a “0 pg/ml” value represents a limit of detection rather than absolute absence of the detected protein