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Table 4 Significant histologic lesions noted in mice after AE challenge with EEEV

From: Eastern equine encephalitis virus in mice II: pathogenesis is dependent on route of exposure

Tissue 6 hpi 12 hpi 1 dpi 2 dpi 3 dpi 4 dpi 5 dpi
6 7 8 9 10 6 7 8 9 10 6 7 8 9 10 6 7 8 9 10 6 7 8 9 10 6 7 8 9 10 6 7 8 9 10
Nasal cavity Inflammation - - - - - - - - - - - - - - - - - - 3mf - 3fe - - 3fe - - - - - - 3mf - - 3fe 3mf
Single cell death - - - - - - - - - - - ++ ± - ± ++ ++ - ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ - ++ ++ ++ ++ ++
Tooth Inflammation - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Single cell death - - - - - - - - - - - - - - - - - - - ± ± ± - ± ± ± ± ± - - ± ± ± - ±
Bone Single cell death - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Eyes Ganglion cell loss - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Olfactory bulb Vacuolation - - - - - - - - - - - - - - - - ± - - - - ± ± - ± ± - ± - - ± - ± ± ±
Single cell death - - - - - - - - - - - - - - - ± ± - - - ++ ++ ++ ++ ++ ++ ++ ++ ++ - ++ - ++ ++ ++
Cerebrum Inflammation - - - - - - - - - - - - - - - - - - - - - - - - ++ ± ± ± - - ++ - ++ ± ±
Single cell death - - - - - - - - - - - - - - - - - - - - - - ++ - - - - - - - - - - - -
Cerebellum Inflammation - - - - - - - - - - - - - - - - - - - - 3d - 2mf - 4mf - - 3d 3d - 3d - 3d - 3mf
Single cell death - - - - - - - - - - - - - - - ± - - - - ++ ± ++ ± ++ ++ ++ ++ ++ - ++ - ++ ++ ++
Brain stem Inflammation - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Single cell death - - - - - - - - - - - - - - - - - - - - ± - ± - - ± ± ± ± - ± ± ± ± ±
Spinal Cord Vacuolation - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 3mf -
Single cell death - - - - - - - - - - - - - - - - - - - - ± - ± - - - - - - - ± ± ± ± ±
Lung Hemorrhage - - - - - - - - - - - - - - - - - - - - - - - - - ± - - - - - - - - -
Inflammation - - - - - - - - - - - - - - - - - - - - - - - - - ± ± ± - - ± - ± ± ±
Single cell death - - - - - - - - - - ± - ± - - - - - - - - - - - - - ± ± - - - - ± - -
Repro tract Single cell death - - - - - - - - - - - - - - - 2fe - - - - 2fe - - 2mf - - - - - - - - - - -
  1. Symbols (++, ±, −) indicate whether the lesion was present and easily recognized (++); variably present throughout the tissue (±); or not detected histologically (−). A score of 1–5 indicates the severity of the inflammation: 1 (minimal); 2 (mild); 3 (moderate); 4 (marked); 5 (severe). Distribution of the lesion: f (focal); fe (focally extensive); mf (multifocal); d (diffuse)