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Table 4 Significant histologic lesions noted in mice after AE challenge with EEEV

From: Eastern equine encephalitis virus in mice II: pathogenesis is dependent on route of exposure

Tissue

6 hpi

12 hpi

1 dpi

2 dpi

3 dpi

4 dpi

5 dpi

6

7

8

9

10

6

7

8

9

10

6

7

8

9

10

6

7

8

9

10

6

7

8

9

10

6

7

8

9

10

6

7

8

9

10

Nasal cavity

Inflammation

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

3mf

-

3fe

-

-

3fe

-

-

-

-

-

-

3mf

-

-

3fe

3mf

Single cell death

-

-

-

-

-

-

-

-

-

-

-

++

±

-

±

++

++

-

++

++

++

++

++

++

++

++

++

++

++

-

++

++

++

++

++

Tooth

Inflammation

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Single cell death

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

±

±

±

-

±

±

±

±

±

-

-

±

±

±

-

±

Bone

Single cell death

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Eyes

Ganglion cell loss

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Olfactory bulb

Vacuolation

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

±

-

-

-

-

±

±

-

±

±

-

±

-

-

±

-

±

±

±

Single cell death

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

±

±

-

-

-

++

++

++

++

++

++

++

++

++

-

++

-

++

++

++

Cerebrum

Inflammation

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

++

±

±

±

-

-

++

-

++

±

±

Single cell death

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

++

-

-

-

-

-

-

-

-

-

-

-

-

Cerebellum

Inflammation

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

3d

-

2mf

-

4mf

-

-

3d

3d

-

3d

-

3d

-

3mf

Single cell death

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

±

-

-

-

-

++

±

++

±

++

++

++

++

++

-

++

-

++

++

++

Brain stem

Inflammation

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Single cell death

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

±

-

±

-

-

±

±

±

±

-

±

±

±

±

±

Spinal Cord

Vacuolation

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

3mf

-

Single cell death

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

±

-

±

-

-

-

-

-

-

-

±

±

±

±

±

Lung

Hemorrhage

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

±

-

-

-

-

-

-

-

-

-

Inflammation

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

±

±

±

-

-

±

-

±

±

±

Single cell death

-

-

-

-

-

-

-

-

-

-

±

-

±

-

-

-

-

-

-

-

-

-

-

-

-

-

±

±

-

-

-

-

±

-

-

Repro tract

Single cell death

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

2fe

-

-

-

-

2fe

-

-

2mf

-

-

-

-

-

-

-

-

-

-

-

  1. Symbols (++, ±, −) indicate whether the lesion was present and easily recognized (++); variably present throughout the tissue (±); or not detected histologically (−). A score of 1–5 indicates the severity of the inflammation: 1 (minimal); 2 (mild); 3 (moderate); 4 (marked); 5 (severe). Distribution of the lesion: f (focal); fe (focally extensive); mf (multifocal); d (diffuse)