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Fig. 3 | Virology Journal

Fig. 3

From: Eastern equine encephalitis virus in mice II: pathogenesis is dependent on route of exposure

Fig. 3

Immunohistochemical and histologic findings in mice after SC (left footpad) infection with EEEV strain FL93-939. Mice were infected with approximately 30LD50 and were euthanized at specified time points (n = 5). Viral antigen was first detected in the left popliteal (draining) lymph node at 6 hpi (a magnification X400). At the inoculation site, viral antigen was present in synovial cells at 12 hpi (b magnification X200). Viral antigen was found in numerous fibroblasts in the left foot at 2 dpi (c magnification X200). Viral antigen was first detected in the olfactory epithelium at 3 dpi (d magnification X200) and was present throughout the brain, including the cerebellum by 4 dpi (e magnification X20). Within the cerebrum there was meningoencephalitis with vasculitis, thrombosis, hemorrhage (arrows), and spongiosis by 6 dpi (f magnification X400); however, viral antigen was not present around thrombotic vessels (inset, between arrows)

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